| 
                   PRECIGEN, INC.
                   (PGEN) | 
               
                   Ares Trading S.A.
                    (Director) | 
               148757 (S) $6.52 | 
               2021-05-24 | 
           | 
                   LA JOLLA PHARMACEUTICAL CO
                   (LJPC) | 
               
                   TANG KEVIN C
                    (10% owner) | 
               398714 (B) $3.89 | 
               2021-05-24 | 
           | 
                   IRONWOOD PHARMACEUTICALS INC
                   (IRWD) | 
               
                   MCCOURT Thomas A
                    (President and Interim CEO) | 
               1716 (S) $12.25 | 
               2021-05-24 | 
           | 
                   Immunome Inc.
                   (IMNM) | 
               
                   LAMATTINA JOHN L
                    (Director) | 
               5440 (B) $18.51 | 
               2021-05-24 | 
           | 
                   Immunome Inc.
                   (IMNM) | 
               
                   Lefenfeld Michael
                    (Director) | 
               4650 (B) $18.42 | 
               2021-05-24 | 
           | 
                   Morphic Holding, Inc.
                   (MORF) | 
               
                   SPRINGER TIMOTHY A
                    (10% owner) | 
               130000 (B) $46.47 | 
               2021-05-24 | 
           | 
                   SELECTA BIOSCIENCES INC
                   (SELB) | 
               
                   TRABER PETER G
                    (Chief Medical Officer) | 
               17500 (B) $3.40 | 
               2021-05-24 | 
           | 
                   SELECTA BIOSCIENCES INC
                   (SELB) | 
               
                   SPRINGER TIMOTHY A
                    (10% owner) | 
               1900000 (B) $3.64 | 
               2021-05-24 | 
           | 
                   MARRONE BIO INNOVATIONS INC
                   (MBII) | 
               
                   Marrone Pamela G
                    (Director) | 
               31953 (S) $1.55 | 
               2021-05-24 | 
           | 
                   Passage BIO, Inc.
                   (PASG) | 
               
                   Goldsmith Bruce A
                    (CEO and President) | 
               2000 (B) $13.12 | 
               2021-05-21 | 
           | 
                   Passage BIO, Inc.
                   (PASG) | 
               
                   Morris Richard Steven
                    (Chief Financial Officer) | 
               2171 (B) $13.82 | 
               2021-05-21 | 
           | 
                   Denali Therapeutics Inc.
                   (DNLI) | 
               
                   Tessier-Lavigne Marc
                    (Director) | 
               46763 (S) $60.08 | 
               2021-05-21 | 
           | 
                   Repare Therapeutics Inc.
                   (RPTX) | 
               
                   GADICKE ANSBERT
                    (10% owner) | 
               324869 (S) $34.13 | 
               2021-05-21 | 
           | 
                   Savara Inc
                   (SVRA) | 
               
                   Pauls Matthew
                    (CHIEF EXECUTIVE OFFICER) | 
               10000 (B) $1.63 | 
               2021-05-21 | 
           | 
                   Intra-Cellular Therapies, Inc.
                   (ITCI) | 
               
                   Alafi Christopher D
                    (Director) | 
               27675 (S) $40.23 | 
               2021-05-21 | 
           | 
                   CorMedix Inc.
                   (CRMD) | 
               
                   Masson-Hurlburt Elizabeth
                    (EVP, Head of Clinical Ops) | 
               8000 (S) $6.92 | 
               2021-05-21 | 
           | 
                   TEVA PHARMACEUTICAL INDUSTRIES LTD
                   (TEVA) | 
               
                   Drape Eric
                    (Executive VP Global Operations) | 
               40000 (S) $11.01 | 
               2021-05-21 | 
           | 
                   Emmaus Life Sciences, Inc.
                   (EMMA) | 
               
                   Niihara Yutaka
                    (Chairman and CEO) | 
               5100 (B) $1.52 | 
               2021-05-21 | 
           | 
                   ImmunityBio, Inc.
                   (IBRX) | 
               
                   Simon Barry J.
                    (Director) | 
               125000 (S) $16.10 | 
               2021-05-21 | 
           | 
                   Morphic Holding, Inc.
                   (MORF) | 
               
                   Nashat Amir
                    (Director) | 
               232295 (S) $45.50 | 
               2021-05-21 | 
           | 
                   Morphic Holding, Inc.
                   (MORF) | 
               
                   SPRINGER TIMOTHY A
                    (10% owner) | 
               232295 (B) $45.50 | 
               2021-05-21 | 
           | 
                   SELECTA BIOSCIENCES INC
                   (SELB) | 
               
                   SPRINGER TIMOTHY A
                    (10% owner) | 
               2773479 (B) $3.19 | 
               2021-05-21 | 
           | 
                   Shattuck Labs, Inc.
                   (STTK) | 
               
                   Schreiber Taylor
                    (Chief Executive Officer) | 
               10545 (S) $25.31 | 
               2021-05-21 | 
           | 
                   PLURISTEM THERAPEUTICS INC
                   (PSTI) | 
               
                   CLOVER WOLF CAPITAL - LIMITED PARTNERSHIP
                    (10% owner) | 
               410376 (S) $3.88 | 
               2021-05-21 | 
           | 
                   Metacrine, Inc.
                   (MTCR) | 
               
                   Chen Hubert C
                    (Chief Medical Officer) | 
               3289 (B) $3.60 | 
               2021-05-20 | 
           | 
                   ARDELYX, INC.
                   (ARDX) | 
               
                   Blanks Robert
                    (See Remarks) | 
               612 (S) $7.09 | 
               2021-05-20 | 
           | 
                   ARDELYX, INC.
                   (ARDX) | 
               
                   GRAMMER ELIZABETH A
                    (See Remarks) | 
               508 (S) $7.09 | 
               2021-05-20 | 
           | 
                   ARDELYX, INC.
                   (ARDX) | 
               
                   Jacobs Jeffrey W
                    (Chief Scientific Officer) | 
               721 (S) $7.09 | 
               2021-05-20 | 
           | 
                   ARDELYX, INC.
                   (ARDX) | 
               
                   Rodriguez Susan
                    (Chief Commercial Officer) | 
               611 (S) $7.09 | 
               2021-05-20 | 
           | 
                   ARDELYX, INC.
                   (ARDX) | 
               
                   Rosenbaum David P.
                    (Chief Development Officer) | 
               769 (S) $7.09 | 
               2021-05-20 | 
           | 
                   ELI LILLY & Co
                   (LLY) | 
               
                   LILLY ENDOWMENT INC
                    (10% owner) | 
               99931 (S) $200.74 | 
               2021-05-20 | 
           | 
                   Innoviva, Inc.
                   (INVA) | 
               
                   GLAXOSMITHKLINE PLC
                    (10% owner) | 
               32005260 (S) $12.25 | 
               2021-05-20 | 
           | 
                   IDEXX LABORATORIES INC /DE
                   (IDXX) | 
               
                   Turner Kathy V
                    (Senior Vice President) | 
               3000 (S) $540.00 | 
               2021-05-20 | 
           | 
                   Assertio Holdings, Inc.
                   (ASRT) | 
               
                   Patel Ajay
                    (SVP and CAO) | 
               8169 (B) $1.53 | 
               2021-05-20 | 
           | 
                   Assertio Holdings, Inc.
                   (ASRT) | 
               
                   Peisert Daniel A.
                    (President and CEO) | 
               15909 (B) $1.54 | 
               2021-05-20 | 
           | 
                   Assertio Holdings, Inc.
                   (ASRT) | 
               
                   Schwichtenberg Paul
                    (SVP and CFO) | 
               9750 (B) $1.51 | 
               2021-05-20 | 
           | 
                   Oric Pharmaceuticals, Inc.
                   (ORIC) | 
               
                   Chacko Jacob
                    (President and CEO) | 
               7270 (S) $25.09 | 
               2021-05-20 | 
           | 
                   OptiNose, Inc.
                   (OPTN) | 
               
                   Clavelli Victor M
                    (Chief Commercial Officer) | 
               34000 (B) $3.06 | 
               2021-05-20 | 
           | 
                   Oric Pharmaceuticals, Inc.
                   (ORIC) | 
               
                   SCHELLER RICHARD H
                    (Director) | 
               1990 (S) $25.09 | 
               2021-05-20 | 
           | 
                   Phathom Pharmaceuticals, Inc.
                   (PHAT) | 
               
                   TAKEDA PHARMACEUTICAL CO LTD
                    (10% owner) | 
               18746 (S) $35.42 | 
               2021-05-20 | 
           | 
                   TFF Pharmaceuticals, Inc.
                   (TFFP) | 
               
                   Fairbairn Malcolm
                    (Director) | 
               10000 (B) $8.95 | 
               2021-05-19 | 
           | 
                   ALX ONCOLOGY HOLDINGS INC
                   (ALXO) | 
               
                   Pons Jaume
                    (President & CEO) | 
               16700 (S) $55.53 | 
               2021-05-19 | 
           | 
                   Alto Ingredients, Inc.
                   (ALTO) | 
               
                   NATHAN GILBERT E
                    (Director) | 
               5000 (B) $5.38 | 
               2021-05-19 | 
           | 
                   Sierra Oncology, Inc.
                   (SRRA) | 
               
                   DILLY STEPHEN GEORGE
                    (CEO and President) | 
               5000 (B) $17.83 | 
               2021-05-19 | 
           | 
                   Sonnet BioTherapeutics Holdings, Inc.
                   (SONN) | 
               
                   Kenney Richard T
                    (Chief Medical Officer) | 
               10000 (B) $1.55 | 
               2021-05-19 | 
           | 
                   Savara Inc
                   (SVRA) | 
               
                   RAMSAY DAVID A
                    (Director) | 
               5003 (B) $1.58 | 
               2021-05-19 | 
           | 
                   Adicet Bio, Inc.
                   (ACET) | 
               
                   Schor Chen
                    (President & CEO) | 
               16466 (S) $13.58 | 
               2021-05-19 | 
           | 
                   Moderna, Inc.
                   (MRNA) | 
               
                   Bancel Stephane
                    (Chief Executive Officer) | 
               21000 (S) $105.22 | 
               2021-05-19 | 
           | 
                   SPRUCE BIOSCIENCES, INC.
                   (SPRB) | 
               
                   Novo Holdings A/S
                    (10% owner) | 
               475000 (S) $13.90 | 
               2021-05-19 | 
           | 
                   Kraig Biocraft Laboratories, Inc
                   (KBLB) | 
               
                   Thompson Kimberly Kraig
                    (CEO & CFO) | 
               70000 (S) $0.00 | 
               2021-05-18 | 
           | 
                   Liquidia Corp
                   (LQDA) | 
               
                   Schundler Russell
                    (General Counsel) | 
               97755 (B) $2.77 | 
               2021-05-18 | 
           | 
                   ALBEMARLE CORP
                   (ALB) | 
               
                   Crawford Raphael Goszcz
                    (President, Catalysts) | 
               6296 (S) $160.08 | 
               2021-05-18 | 
           | 
                   Angion Biomedica Corp.
                   (ANGN) | 
               
                   Neylan John F.
                    (See Remarks) | 
               363 (S) $13.91 | 
               2021-05-18 | 
           | 
                   Brickell Biotech, Inc.
                   (BBI) | 
               
                   Chadha Deepak
                    (Chief Research & Dev. Officer) | 
               15200 (B) $0.82 | 
               2021-05-18 | 
           | 
                   CF Industries Holdings, Inc.
                   (CF) | 
               
                   Frost Bert A
                    (Sr.VP,Sales,Mkt Dev&SuppChn) | 
               5000 (S) $56.00 | 
               2021-05-18 | 
           | 
                   POLARITYTE, INC.
                   (PTE) | 
               
                   COHEN PETER A
                    (Director) | 
               265000 (B) $0.98 | 
               2021-05-18 | 
           | 
                   TFF Pharmaceuticals, Inc.
                   (TFFP) | 
               
                   THURMAN RANDY H
                    (Director) | 
               1050 (B) $9.40 | 
               2021-05-18 | 
           | 
                   Adicet Bio, Inc.
                   (ACET) | 
               
                   Jakobovits Aya
                    (Director) | 
               8000 (S) $14.14 | 
               2021-05-18 | 
           | 
                   Apellis Pharmaceuticals, Inc.
                   (APLS) | 
               
                   Dunlop A. Sinclair
                    (Director) | 
               162873 (S) $52.25 | 
               2021-05-18 | 
           | 
                   PRECIGEN, INC.
                   (PGEN) | 
               
                   Ares Trading S.A.
                    (10% owner) | 
               255543 (S) $6.68 | 
               2021-05-18 | 
           | 
                   Atara Biotherapeutics, Inc.
                   (ATRA) | 
               
                   Yarema Kristin
                    (Chief Commercial Officer) | 
               761 (S) $14.55 | 
               2021-05-18 | 
           | 
                   Atara Biotherapeutics, Inc.
                   (ATRA) | 
               
                   Koppikar Utpal
                    (Chief Financial Officer) | 
               3616 (S) $14.55 | 
               2021-05-18 | 
           | 
                   Atara Biotherapeutics, Inc.
                   (ATRA) | 
               
                   Dupont Jakob
                    (EVP, Head of R&D) | 
               5184 (S) $14.55 | 
               2021-05-18 | 
           | 
                   Atara Biotherapeutics, Inc.
                   (ATRA) | 
               
                   Newell Joe
                    (Chief Operations Officer) | 
               2453 (S) $14.55 | 
               2021-05-18 | 
           | 
                   OCEAN BIO CHEM INC
                   (OBCI) | 
               
                   DORNAU PETER G
                    (Chairman, President, & CEO) | 
               100 (B) $12.79 | 
               2021-05-18 | 
           | 
                   Repare Therapeutics Inc.
                   (RPTX) | 
               
                   GADICKE ANSBERT
                    (10% owner) | 
               68738 (S) $30.34 | 
               2021-05-18 | 
           | 
                   Y-mAbs Therapeutics, Inc.
                   (YMAB) | 
               
                   Gad Thomas
                    (See remarks) | 
               4000 (S) $34.07 | 
               2021-05-18 | 
           | 
                   Marker Therapeutics, Inc.
                   (MRKR) | 
               
                   Wasserman Frederick Gerald
                    (Director) | 
               10000 (B) $2.41 | 
               2021-05-18 | 
           | 
                   Repare Therapeutics Inc.
                   (RPTX) | 
               
                   Segal Lloyd Mitchell
                    (President and CEO) | 
               5600 (S) $35.03 | 
               2021-05-18 | 
           | 
                   aTYR PHARMA INC
                   (LIFE) | 
               
                   SCHIMMEL PAUL
                    (Director) | 
               50000 (B) $3.98 | 
               2021-05-18 | 
           | 
                   Schrodinger, Inc.
                   (SDGR) | 
               
                   SHAW DAVID E
                    (10% owner) | 
               78402 (S) $63.44 | 
               2021-05-18 | 
           | 
                   aTYR PHARMA INC
                   (LIFE) | 
               
                   Shukla Sanjay
                    (President and CEO) | 
               10000 (B) $4.01 | 
               2021-05-18 | 
           | 
                   Shattuck Labs, Inc.
                   (STTK) | 
               
                   Neill Andrew R
                    (Chief Financial Officer) | 
               2000 (S) $26.27 | 
               2021-05-17 | 
           | 
                   Regulus Therapeutics Inc.
                   (RGLS) | 
               
                   Hagan Joseph P
                    (President and CEO) | 
               4186 (S) $0.89 | 
               2021-05-17 | 
           | 
                   Shattuck Labs, Inc.
                   (STTK) | 
               
                   Thomson Erin Ator
                    (General Counsel) | 
               4000 (S) $26.25 | 
               2021-05-17 | 
           | 
                   AdvanSix Inc.
                   (ASIX) | 
               
                   Gramm Christopher
                    (Controller) | 
               200 (S) $30.97 | 
               2021-05-17 | 
           | 
                   Regulus Therapeutics Inc.
                   (RGLS) | 
               
                   Aker Christopher Ray
                    (Sr. VP & General Counsel) | 
               860 (S) $0.89 | 
               2021-05-17 | 
           | 
                   Atara Biotherapeutics, Inc.
                   (ATRA) | 
               
                   Newell Joe
                    (Chief Operations Officer) | 
               3500 (S) $15.00 | 
               2021-05-17 | 
           | 
                   PROCTER & GAMBLE Co
                   (PG) | 
               
                   Francisco Ma. Fatima
                    (CEO - Baby & Feminine Care) | 
               3000 (S) $139.00 | 
               2021-05-17 | 
           | 
                   Frequency Therapeutics, Inc.
                   (FREQ) | 
               
                   McCubbin Quentin
                    (Chief Manufacturing Officer) | 
               10000 (B) $8.85 | 
               2021-05-17 | 
           | 
                   RAPT Therapeutics, Inc.
                   (RAPT) | 
               
                   HO WILLIAM
                    (Chief Medical Officer) | 
               1000 (S) $19.87 | 
               2021-05-17 | 
           | 
                   VERTEX PHARMACEUTICALS INC / MA
                   (VRTX) | 
               
                   Liu Joy
                    (SVP, General Counsel) | 
               112 (S) $216.41 | 
               2021-05-17 | 
           | 
                   NEKTAR THERAPEUTICS
                   (NKTR) | 
               
                   ROBIN HOWARD W
                    (President & CEO) | 
               11560 (S) $18.30 | 
               2021-05-17 | 
           | 
                   Renewable Energy Group, Inc.
                   (REGI) | 
               
                   Sorrells Christopher D.
                    (Director) | 
               15000 (S) $63.53 | 
               2021-05-17 | 
           | 
                   VERTEX PHARMACEUTICALS INC / MA
                   (VRTX) | 
               
                   Sanna Bastiano
                    (EVP, Cell & Genetic Therapies) | 
               112 (S) $216.41 | 
               2021-05-17 | 
           | 
                   VERTEX PHARMACEUTICALS INC / MA
                   (VRTX) | 
               
                   ALTSHULER DAVID
                    (EVP, Global Research and CSO) | 
               79 (S) $216.25 | 
               2021-05-17 | 
           | 
                   VERTEX PHARMACEUTICALS INC / MA
                   (VRTX) | 
               
                   Arbuckle Stuart A
                    (EVP, Chief Comm & Ops Officer) | 
               109 (S) $216.28 | 
               2021-05-17 | 
           | 
                   Brickell Biotech, Inc.
                   (BBI) | 
               
                   McAvoy David R.
                    (General Counsel and CCO) | 
               26602 (B) $0.80 | 
               2021-05-17 | 
           | 
                   Celanese Corp
                   (CE) | 
               
                   Richardson Scott A
                    (EVP & CFO) | 
               6500 (S) $166.65 | 
               2021-05-17 | 
           | 
                   CorMedix Inc.
                   (CRMD) | 
               
                   Kaplan Myron
                    (Director) | 
               15000 (B) $6.03 | 
               2021-05-17 | 
           | 
                   Allakos Inc.
                   (ALLK) | 
               
                   Alexander Robert
                    (Chief Executive Officer) | 
               60000 (S) $100.30 | 
               2021-05-17 | 
           | 
                   Horizon Therapeutics Public Ltd Co
                   (HZNP) | 
               
                   Hoelscher Paul W.
                    (EVP, CFO) | 
               102925 (S) $90.01 | 
               2021-05-14 | 
           | 
                   EXELIXIS, INC.
                   (EXEL) | 
               
                   POSTE GEORGE
                    (Director) | 
               40802 (S) $24.97 | 
               2021-05-14 | 
           | 
                   INTERNATIONAL FLAVORS & FRAGRANCES INC
                   (IFF) | 
               
                   GORDON ILENE S
                    (Director) | 
               1000 (B) $140.39 | 
               2021-05-14 | 
           | 
                   Taysha Gene Therapies, Inc.
                   (TSHA) | 
               
                   Manning Paul B
                    (10% owner) | 
               12000 (B) $20.98 | 
               2021-05-14 | 
           | 
                   Vericel Corp
                   (VCEL) | 
               
                   Wotton Paul K
                    (Other) | 
               5000 (S) $50.52 | 
               2021-05-14 | 
           | 
                   ARCA biopharma, Inc.
                   (ABIO) | 
               
                   CONWAY ROBERT E
                    (Chairman of the Board) | 
               10000 (B) $3.19 | 
               2021-05-13 | 
           | 
                   EASTMAN CHEMICAL CO
                   (EMN) | 
               
                   King Scott V.
                    (CAO & Controller) | 
               12588 (S) $126.00 | 
               2021-05-13 | 
           | 
                   Kraig Biocraft Laboratories, Inc
                   (KBLB) | 
               
                   Thompson Kimberly Kraig
                    (CEO & CFO) | 
               15000 (S) $0.00 | 
               2021-05-13 | 
           | 
                   SPECTRUM PHARMACEUTICALS INC
                   (SPPI) | 
               
                   McGahan Keith M
                    (Chief Legal Officer) | 
               959 (S) $3.08 | 
               2021-05-13 |