| 
                   Aravive, Inc.
                   (ARAV) | 
               
                   McIntyre Gail Frances
                    (CEO and President) | 
               1000 (B) $5.34 | 
               2021-06-29 | 
           | 
                   Adaptimmune Therapeutics PLC
                   (ADAP) | 
               
                   Rawcliffe Adrian
                    (Chief Executive Officer) | 
               2794 (S) $4.37 | 
               2021-06-28 | 
           | 
                   Kala Pharmaceuticals, Inc.
                   (KALA) | 
               
                   Bazemore Todd
                    (CHIEF OPERATING OFFICER) | 
               2911 (S) $5.77 | 
               2021-06-28 | 
           | 
                   Kala Pharmaceuticals, Inc.
                   (KALA) | 
               
                   Brazzell Romulus K
                    (CHIEF MEDICAL OFFICER) | 
               3034 (S) $5.77 | 
               2021-06-28 | 
           | 
                   CEL SCI CORP
                   (CVM) | 
               
                   YOUNG PETER R
                    (Director) | 
               3000 (B) $12.66 | 
               2021-06-28 | 
           | 
                   Kala Pharmaceuticals, Inc.
                   (KALA) | 
               
                   Chen Hongming
                    (CHIEF SCIENTIFIC OFFICER) | 
               2452 (S) $5.77 | 
               2021-06-28 | 
           | 
                   Cortexyme, Inc.
                   (CRTX) | 
               
                   McLoughlin Margaret
                    (Director) | 
               550 (S) $55.26 | 
               2021-06-28 | 
           | 
                   TYME TECHNOLOGIES, INC.
                   (TYME) | 
               
                   Demurjian Michael
                    (10% owner) | 
               20000 (S) $1.32 | 
               2021-06-28 | 
           | 
                   Intellia Therapeutics, Inc.
                   (NTLA) | 
               
                   FORMELA JEAN FRANCOIS
                    (Director) | 
               553376 (S) $135.32 | 
               2021-06-28 | 
           | 
                   Fulcrum Therapeutics, Inc.
                   (FULC) | 
               
                   GERAGHTY JAMES A
                    (Director) | 
               10000 (B) $9.16 | 
               2021-06-28 | 
           | 
                   Fulcrum Therapeutics, Inc.
                   (FULC) | 
               
                   Thomson Peter G.
                    (VP Finance & Accounting) | 
               2300 (B) $9.00 | 
               2021-06-28 | 
           | 
                   Fulcrum Therapeutics, Inc.
                   (FULC) | 
               
                   Oltmans Curtis Gale
                    (SVP, General Counsel) | 
               1088 (B) $9.01 | 
               2021-06-28 | 
           | 
                   Fulcrum Therapeutics, Inc.
                   (FULC) | 
               
                   Morabito Christopher
                    (Chief Medical Officer) | 
               1100 (B) $9.16 | 
               2021-06-28 | 
           | 
                   Kala Pharmaceuticals, Inc.
                   (KALA) | 
               
                   Iwicki Mark T
                    (CHIEF EXECUTIVE OFFICER) | 
               7586 (S) $5.77 | 
               2021-06-28 | 
           | 
                   Kala Pharmaceuticals, Inc.
                   (KALA) | 
               
                   Reumuth Mary
                    (CHIEF FINANCIAL OFFICER) | 
               2452 (S) $5.77 | 
               2021-06-28 | 
           | 
                   Kala Pharmaceuticals, Inc.
                   (KALA) | 
               
                   Trachtenberg Eric
                    (SEE REMARKS) | 
               2452 (S) $5.77 | 
               2021-06-28 | 
           | 
                   Kraig Biocraft Laboratories, Inc
                   (KBLB) | 
               
                   Thompson Kimberly Kraig
                    (CEO & CFO) | 
               28572 (S) $0.00 | 
               2021-06-28 | 
           | 
                   Phathom Pharmaceuticals, Inc.
                   (PHAT) | 
               
                   Socks David A
                    (Director) | 
               40000 (S) $34.39 | 
               2021-06-28 | 
           | 
                   ALBIREO PHARMA, INC.
                   (ALBO) | 
               
                   Stephenson Pamela
                    (Chief Commercial Officer) | 
               471 (S) $36.01 | 
               2021-06-25 | 
           | 
                   Kraig Biocraft Laboratories, Inc
                   (KBLB) | 
               
                   Thompson Kimberly Kraig
                    (CEO & CFO) | 
               50000 (S) $0.00 | 
               2021-06-25 | 
           | 
                   ALPINE IMMUNE SCIENCES, INC.
                   (ALPN) | 
               
                   GOLD MITCHELL
                    (Executive Chairman and CEO) | 
               12952 (S) $10.01 | 
               2021-06-25 | 
           | 
                   Alzamend Neuro, Inc.
                   (ALZN) | 
               
                   AULT MILTON C III
                    (Other) | 
               300 (S) $10.06 | 
               2021-06-25 | 
           | 
                   Atara Biotherapeutics, Inc.
                   (ATRA) | 
               
                   Touchon Pascal
                    (President and CEO) | 
               14194 (S) $16.32 | 
               2021-06-25 | 
           | 
                   BioXcel Therapeutics, Inc.
                   (BTAI) | 
               
                   BioXcel Holdings, Inc.
                    (10% owner) | 
               473250 (S) $30.83 | 
               2021-06-25 | 
           | 
                   BioXcel Therapeutics, Inc.
                   (BTAI) | 
               
                   BioXcel LLC
                    (10% owner) | 
               473250 (S) $30.83 | 
               2021-06-25 | 
           | 
                   BioXcel Therapeutics, Inc.
                   (BTAI) | 
               
                   Nandabalan Krishnan
                    (Director) | 
               473250 (S) $30.83 | 
               2021-06-25 | 
           | 
                   BioXcel Therapeutics, Inc.
                   (BTAI) | 
               
                   Mehta Vimal
                    (CEO, President and Secretary) | 
               473250 (S) $30.83 | 
               2021-06-25 | 
           | 
                   CHIMERIX INC
                   (CMRX) | 
               
                   MIDDLETON FRED A
                    (Director) | 
               10000 (B) $7.80 | 
               2021-06-25 | 
           | 
                   XOMA Corp
                   (XOMA) | 
               
                   Neal James R
                    (CEO) | 
               9027 (S) $34.27 | 
               2021-06-25 | 
           | 
                   Phathom Pharmaceuticals, Inc.
                   (PHAT) | 
               
                   TAKEDA PHARMACEUTICAL CO LTD
                    (10% owner) | 
               24501 (S) $35.54 | 
               2021-06-25 | 
           | 
                   Royalty Pharma plc
                   (RPRX) | 
               
                   RIGGS RORY B
                    (Director) | 
               1314912 (S) $42.17 | 
               2021-06-25 | 
           | 
                   Arcutis Biotherapeutics, Inc.
                   (ARQT) | 
               
                   CHAUDHURI BHASKAR
                    (Director) | 
               7484 (S) $27.50 | 
               2021-06-24 | 
           | 
                   PRECIGEN, INC.
                   (PGEN) | 
               
                   Ares Trading S.A.
                    (10% owner) | 
               359093 (S) $6.79 | 
               2021-06-24 | 
           | 
                   Emmaus Life Sciences, Inc.
                   (EMMA) | 
               
                   Niihara Yutaka
                    (Chairman and CEO) | 
               3800 (B) $1.49 | 
               2021-06-24 | 
           | 
                   Repare Therapeutics Inc.
                   (RPTX) | 
               
                   GADICKE ANSBERT
                    (10% owner) | 
               28688 (S) $33.52 | 
               2021-06-24 | 
           | 
                   Generation Bio Co.
                   (GBIO) | 
               
                   Rhodes Jason P
                    (Director) | 
               31008 (S) $26.08 | 
               2021-06-24 | 
           | 
                   MARRONE BIO INNOVATIONS INC
                   (MBII) | 
               
                   Marrone Pamela G
                    (Director) | 
               13662 (S) $1.79 | 
               2021-06-24 | 
           | 
                   Galecto, Inc.
                   (GLTO) | 
               
                   Winslow Garrett
                    (General Counsel) | 
               2000 (B) $4.80 | 
               2021-06-23 | 
           | 
                   KEMPHARM, INC
                   (KMPH) | 
               
                   Clifton R. LaDuane
                    (CFO, Secretary & Treasurer) | 
               75 (B) $14.11 | 
               2021-06-23 | 
           | 
                   9 METERS BIOPHARMA, INC.
                   (NMTR) | 
               
                   OrbiMed Israel GP Ltd.
                    (10% owner) | 
               17150781 (S) $1.32 | 
               2021-06-23 | 
           | 
                   Alzamend Neuro, Inc.
                   (ALZN) | 
               
                   AULT MILTON C III
                    (Other) | 
               12000 (B) $8.60 | 
               2021-06-23 | 
           | 
                   HUMANIGEN, INC
                   (HGEN) | 
               
                   Chappell Dale
                    (Chief Scientific Officer) | 
               1272655 (S) $18.15 | 
               2021-06-23 | 
           | 
                   Moderna, Inc.
                   (MRNA) | 
               
                   Bancel Stephane
                    (Chief Executive Officer) | 
               21000 (S) $144.48 | 
               2021-06-23 | 
           | 
                   Green Plains Inc.
                   (GPRE) | 
               
                   Kolomaya Paul E
                    (Chief Accounting Officer) | 
               1500 (S) $33.50 | 
               2021-06-23 | 
           | 
                   Shattuck Labs, Inc.
                   (STTK) | 
               
                   Hornblower Josiah
                    (Director) | 
               29658 (S) $28.22 | 
               2021-06-23 | 
           | 
                   Reneo Pharmaceuticals, Inc.
                   (RPHM) | 
               
                   Muralidhar Bali
                    (Director) | 
               20710 (B) $9.28 | 
               2021-06-23 | 
           | 
                   Phathom Pharmaceuticals, Inc.
                   (PHAT) | 
               
                   TAKEDA PHARMACEUTICAL CO LTD
                    (10% owner) | 
               11048 (S) $35.07 | 
               2021-06-23 | 
           | 
                   SPECTRUM PHARMACEUTICALS INC
                   (SPPI) | 
               
                   LEBEL FRANCOIS
                    (Chief Medical Officer) | 
               10821 (S) $4.04 | 
               2021-06-22 | 
           | 
                   ARROWHEAD PHARMACEUTICALS, INC.
                   (ARWR) | 
               
                   GIVEN DOUGLAS B
                    (Director) | 
               4500 (S) $89.21 | 
               2021-06-22 | 
           | 
                   ATAI Life Sciences N.V.
                   (ATAI) | 
               
                   WEAVER GREGORY L
                    (Chief Financial Officer) | 
               4666 (B) $15.00 | 
               2021-06-22 | 
           | 
                   ATAI Life Sciences N.V.
                   (ATAI) | 
               
                   Brand Florian
                    (See Remarks) | 
               2333 (B) $15.00 | 
               2021-06-22 | 
           | 
                   ATAI Life Sciences N.V.
                   (ATAI) | 
               
                   Rao Srinivas
                    (See Remarks) | 
               3500 (B) $15.00 | 
               2021-06-22 | 
           | 
                   ATAI Life Sciences N.V.
                   (ATAI) | 
               
                   Angermayer Christian
                    (10% owner) | 
               700000 (B) $15.00 | 
               2021-06-22 | 
           | 
                   ATAI Life Sciences N.V.
                   (ATAI) | 
               
                   de Rosnay Alexis
                    (Director) | 
               4666 (B) $15.00 | 
               2021-06-22 | 
           | 
                   ATAI Life Sciences N.V.
                   (ATAI) | 
               
                   Smiley Andrea Heslin
                    (Director) | 
               4666 (B) $15.00 | 
               2021-06-22 | 
           | 
                   Schrodinger, Inc.
                   (SDGR) | 
               
                   SHAW DAVID E
                    (10% owner) | 
               299027 (S) $78.28 | 
               2021-06-22 | 
           | 
                   Turning Point Therapeutics, Inc.
                   (TPTX) | 
               
                   Alles Mark J
                    (Director) | 
               2000 (B) $81.34 | 
               2021-06-21 | 
           | 
                   Adamas Pharmaceuticals Inc
                   (ADMS) | 
               
                   Shreedhar Vijay
                    (Chief Commercial Officer) | 
               6200 (S) $5.16 | 
               2021-06-21 | 
           | 
                   Aptose Biosciences Inc.
                   (APTO) | 
               
                   Whitehead Warren
                    (Director) | 
               25000 (S) $3.29 | 
               2021-06-21 | 
           | 
                   MACROGENICS INC
                   (MGNX) | 
               
                   BIOTECH TARGET N V
                    (10% owner) | 
               75000 (B) $21.74 | 
               2021-06-21 | 
           | 
                   Clearside Biomedical, Inc.
                   (CLSD) | 
               
                   LASEZKAY GEORGE M
                    (CEO) | 
               3707 (S) $4.38 | 
               2021-06-21 | 
           | 
                   Kodiak Sciences Inc.
                   (KOD) | 
               
                   EHRLICH JASON
                    (See Remarks) | 
               6950 (S) $84.31 | 
               2021-06-21 | 
           | 
                   Repare Therapeutics Inc.
                   (RPTX) | 
               
                   GADICKE ANSBERT
                    (10% owner) | 
               42798 (S) $33.77 | 
               2021-06-21 | 
           | 
                   Generation Bio Co.
                   (GBIO) | 
               
                   Rhodes Jason P
                    (Director) | 
               185078 (S) $25.11 | 
               2021-06-21 | 
           | 
                   Nkarta, Inc.
                   (NKTX) | 
               
                   HASTINGS PAUL J
                    (Chief Executive Officer) | 
               8500 (S) $26.64 | 
               2021-06-21 | 
           | 
                   Reneo Pharmaceuticals, Inc.
                   (RPHM) | 
               
                   Muralidhar Bali
                    (Director) | 
               47274 (B) $8.88 | 
               2021-06-21 | 
           | 
                   Olema Pharmaceuticals, Inc.
                   (OLMA) | 
               
                   Harmon Cyrus
                    (CHIEF TECHNOLOGY OFFICER) | 
               12000 (S) $25.48 | 
               2021-06-18 | 
           | 
                   Angion Biomedica Corp.
                   (ANGN) | 
               
                   Neylan John F.
                    (See Remarks) | 
               366 (S) $13.20 | 
               2021-06-18 | 
           | 
                   BeiGene, Ltd.
                   (BGNE) | 
               
                   Liang Howard
                    (CFO & Chief Strategy Officer) | 
               486 (S) $325.89 | 
               2021-06-18 | 
           | 
                   C4 Therapeutics, Inc.
                   (CCCC) | 
               
                   Salter Malcolm
                    (Director) | 
               755 (S) $37.19 | 
               2021-06-18 | 
           | 
                   Checkmate Pharmaceuticals, Inc.
                   (CMPI) | 
               
                   Krieg Arthur M
                    (Chief Scientific Officer) | 
               7224 (B) $6.04 | 
               2021-06-18 | 
           | 
                   Evofem Biosciences, Inc.
                   (EVFM) | 
               
                   Kamdar Kim P.
                    (Director) | 
               10000 (B) $1.17 | 
               2021-06-18 | 
           | 
                   IDERA PHARMACEUTICALS, INC.
                   (IDRA) | 
               
                   SOLAND DANIEL B
                    (CHIEF OPERATING OFFICER) | 
               50000 (B) $1.19 | 
               2021-06-18 | 
           | 
                   Kraig Biocraft Laboratories, Inc
                   (KBLB) | 
               
                   Thompson Kimberly Kraig
                    (CEO & CFO) | 
               30000 (S) $0.00 | 
               2021-06-18 | 
           | 
                   USANA HEALTH SCIENCES INC
                   (USNA) | 
               
                   Neidig Brent
                    (Chief Officer & MD of China) | 
               259 (S) $102.17 | 
               2021-06-18 | 
           | 
                   OptiNose, Inc.
                   (OPTN) | 
               
                   Goldan Keith A.
                    (Chief Financial Officer) | 
               576 (S) $3.73 | 
               2021-06-17 | 
           | 
                   OptiNose, Inc.
                   (OPTN) | 
               
                   Mahmoud Ramy A
                    (President and COO) | 
               909 (S) $3.73 | 
               2021-06-17 | 
           | 
                   MYRIAD GENETICS INC
                   (MYGN) | 
               
                   SPIEGELMAN DANIEL K
                    (Director) | 
               3139 (S) $30.52 | 
               2021-06-17 | 
           | 
                   OptiNose, Inc.
                   (OPTN) | 
               
                   Marino Michael F III
                    (Chief Legal Officer & Corp Sec) | 
               576 (S) $3.73 | 
               2021-06-17 | 
           | 
                   Repare Therapeutics Inc.
                   (RPTX) | 
               
                   Foley Todd
                    (Director) | 
               18294 (S) $33.85 | 
               2021-06-17 | 
           | 
                   Repare Therapeutics Inc.
                   (RPTX) | 
               
                   GADICKE ANSBERT
                    (10% owner) | 
               41518 (S) $33.85 | 
               2021-06-17 | 
           | 
                   BIO-TECHNE Corp
                   (TECH) | 
               
                   Kummeth Charles R.
                    (Chief Executive Officer) | 
               12498 (S) $450.48 | 
               2021-06-17 | 
           | 
                   Verve Therapeutics, Inc.
                   (VERV) | 
               
                   Beaudoin Margaret
                    (Vice President, Finance) | 
               1000 (B) $19.00 | 
               2021-06-17 | 
           | 
                   Verve Therapeutics, Inc.
                   (VERV) | 
               
                   Kathiresan Sekar
                    (Chief Executive Officer) | 
               2500 (B) $19.00 | 
               2021-06-17 | 
           | 
                   Phathom Pharmaceuticals, Inc.
                   (PHAT) | 
               
                   TAKEDA PHARMACEUTICAL CO LTD
                    (10% owner) | 
               8703 (S) $35.11 | 
               2021-06-17 | 
           | 
                   Schrodinger, Inc.
                   (SDGR) | 
               
                   SHAW DAVID E
                    (10% owner) | 
               165178 (S) $74.78 | 
               2021-06-17 | 
           | 
                   Kindred Biosciences, Inc.
                   (KIN) | 
               
                   Chin Richard
                    (Chief Executive Officer) | 
               40000 (S) $9.18 | 
               2021-06-16 | 
           | 
                   Sage Therapeutics, Inc.
                   (SAGE) | 
               
                   FRATES JAMES M
                    (Other) | 
               1810 (B) $55.10 | 
               2021-06-16 | 
           | 
                   Checkmate Pharmaceuticals, Inc.
                   (CMPI) | 
               
                   Krieg Arthur M
                    (Chief Scientific Officer) | 
               3578 (B) $6.18 | 
               2021-06-16 | 
           | 
                   Sage Therapeutics, Inc.
                   (SAGE) | 
               
                   Greene Barry E
                    (President and CEO) | 
               8800 (B) $56.32 | 
               2021-06-16 | 
           | 
                   Neoleukin Therapeutics, Inc.
                   (NLTX) | 
               
                   Walkey Carl
                    (Senior Vice President) | 
               600 (S) $10.19 | 
               2021-06-16 | 
           | 
                   Sage Therapeutics, Inc.
                   (SAGE) | 
               
                   STARR KEVIN P
                    (Other) | 
               17842 (B) $56.05 | 
               2021-06-16 | 
           | 
                   AdvanSix Inc.
                   (ASIX) | 
               
                   Gramm Christopher
                    (Controller) | 
               200 (S) $29.83 | 
               2021-06-16 | 
           | 
                   Arcus Biosciences, Inc.
                   (RCUS) | 
               
                   Jaen Juan C.
                    (President) | 
               4857 (S) $24.19 | 
               2021-06-16 | 
           | 
                   Adicet Bio, Inc.
                   (ACET) | 
               
                   Schor Chen
                    (President & CEO) | 
               16466 (S) $10.53 | 
               2021-06-16 | 
           | 
                   Arcus Biosciences, Inc.
                   (RCUS) | 
               
                   Tang Carolyn C.
                    (General Counsel) | 
               2915 (S) $24.19 | 
               2021-06-16 | 
           | 
                   Moderna, Inc.
                   (MRNA) | 
               
                   Bancel Stephane
                    (Chief Executive Officer) | 
               21000 (S) $133.33 | 
               2021-06-16 | 
           | 
                   Brooklyn ImmunoTherapeutics, Inc.
                   (BTX) | 
               
                   Cherington Charles
                    (Other) | 
               400000 (S) $15.92 | 
               2021-06-16 | 
           | 
                   CytomX Therapeutics, Inc.
                   (CTMX) | 
               
                   McCarthy Sean A.
                    (President and CEO) | 
               100000 (S) $7.04 | 
               2021-06-16 | 
           | 
                   Seagen Inc.
                   (SGEN) | 
               
                   DANSEY ROGER D
                    (Chief Medical Officer) | 
               25109 (S) $152.22 | 
               2021-06-16 |