| 
                   VERU INC.
                   (VERU) | 
               
                   FISCH HARRY
                    (10% owner) | 
               100000 (S) $8.35 | 
               2021-06-16 | 
           | 
                   Replimune Group, Inc.
                   (REPL) | 
               
                   Love Colin
                    (Chief Operating Officer) | 
               30000 (S) $34.16 | 
               2021-06-15 | 
           | 
                   Shattuck Labs, Inc.
                   (STTK) | 
               
                   Neill Andrew R
                    (Chief Financial Officer) | 
               2000 (S) $27.53 | 
               2021-06-15 | 
           | 
                   Shattuck Labs, Inc.
                   (STTK) | 
               
                   Thomson Erin Ator
                    (General Counsel) | 
               4000 (S) $27.55 | 
               2021-06-15 | 
           | 
                   MACROGENICS INC
                   (MGNX) | 
               
                   BIOTECH TARGET N V
                    (10% owner) | 
               175000 (B) $20.79 | 
               2021-06-15 | 
           | 
                   PDS Biotechnology Corp
                   (PDSB) | 
               
                   Freitag Gregory Gene
                    (Other) | 
               5882 (B) $8.50 | 
               2021-06-15 | 
           | 
                   PDS Biotechnology Corp
                   (PDSB) | 
               
                   Glover Steve C
                    (Other) | 
               5882 (B) $8.50 | 
               2021-06-15 | 
           | 
                   PDS Biotechnology Corp
                   (PDSB) | 
               
                   VAN VOORHEES SETH
                    (Chief Financial Officer) | 
               17647 (B) $8.50 | 
               2021-06-15 | 
           | 
                   Adaptive Biotechnologies Corp
                   (ADPT) | 
               
                   ROBINS CHAD M
                    (CEO and Chairman) | 
               30000 (S) $38.78 | 
               2021-06-15 | 
           | 
                   Adicet Bio, Inc.
                   (ACET) | 
               
                   Jakobovits Aya
                    (Director) | 
               3847 (S) $11.16 | 
               2021-06-15 | 
           | 
                   PDS Biotechnology Corp
                   (PDSB) | 
               
                   Ali-Jackson Kamil
                    (Other) | 
               11764 (B) $8.50 | 
               2021-06-15 | 
           | 
                   Cryoport, Inc.
                   (CYRX) | 
               
                   Blackstone Freeze Parent L.P.
                    (10% owner) | 
               200000 (S) $60.00 | 
               2021-06-15 | 
           | 
                   Cryoport, Inc.
                   (CYRX) | 
               
                   Blackstone Holdings II L.P.
                    (10% owner) | 
               200000 (S) $60.00 | 
               2021-06-15 | 
           | 
                   Emmaus Life Sciences, Inc.
                   (EMMA) | 
               
                   Niihara Yutaka
                    (Chairman and CEO) | 
               2490 (B) $1.60 | 
               2021-06-15 | 
           | 
                   Galera Therapeutics, Inc.
                   (GRTX) | 
               
                   West Linda
                    (Director) | 
               10000 (B) $9.13 | 
               2021-06-15 | 
           | 
                   Green Plains Inc.
                   (GPRE) | 
               
                   MAPES MICHELLE
                    (Chief Legal and Admin Officer) | 
               1800 (S) $34.25 | 
               2021-06-15 | 
           | 
                   RAPT Therapeutics, Inc.
                   (RAPT) | 
               
                   HO WILLIAM
                    (Chief Medical Officer) | 
               1000 (S) $43.26 | 
               2021-06-15 | 
           | 
                   TYME TECHNOLOGIES, INC.
                   (TYME) | 
               
                   Demurjian Michael
                    (10% owner) | 
               20000 (S) $1.43 | 
               2021-06-14 | 
           | 
                   KEMPHARM, INC
                   (KMPH) | 
               
                   Mickle Travis C
                    (President & CEO) | 
               1500 (B) $14.43 | 
               2021-06-14 | 
           | 
                   Evofem Biosciences, Inc.
                   (EVFM) | 
               
                   O'Brien Anthony Stephen
                    (Director) | 
               8140 (B) $1.31 | 
               2021-06-14 | 
           | 
                   Adaptive Biotechnologies Corp
                   (ADPT) | 
               
                   ADAMS R MARK
                    (Chief Operating Officer) | 
               8914 (S) $38.77 | 
               2021-06-14 | 
           | 
                   Synaptogenix, Inc.
                   (SNPX) | 
               
                   Alkon Daniel L.
                    (Chief Scientific Officer) | 
               10000 (B) $8.26 | 
               2021-06-14 | 
           | 
                   Allakos Inc.
                   (ALLK) | 
               
                   Tomasi Adam
                    (President and COO) | 
               40000 (S) $91.32 | 
               2021-06-14 | 
           | 
                   Angion Biomedica Corp.
                   (ANGN) | 
               
                   Rhodes Jennifer J
                    (See Remarks) | 
               427 (S) $13.27 | 
               2021-06-14 | 
           | 
                   Avidity Biosciences, Inc.
                   (RNA) | 
               
                   LEVIN ARTHUR A
                    (Chief Scientific Officer) | 
               37022 (S) $25.97 | 
               2021-06-14 | 
           | 
                   IRONWOOD PHARMACEUTICALS INC
                   (IRWD) | 
               
                   Currie Mark G
                    (Director) | 
               23571 (S) $11.59 | 
               2021-06-14 | 
           | 
                   Repare Therapeutics Inc.
                   (RPTX) | 
               
                   GADICKE ANSBERT
                    (10% owner) | 
               6227 (S) $33.21 | 
               2021-06-14 | 
           | 
                   Twist Bioscience Corp
                   (TWST) | 
               
                   Green Paula
                    (SVP of Human Resources) | 
               14161 (S) $114.42 | 
               2021-06-14 | 
           | 
                   Shattuck Labs, Inc.
                   (STTK) | 
               
                   Hornblower Josiah
                    (Director) | 
               21340 (S) $28.11 | 
               2021-06-14 | 
           | 
                   Schrodinger, Inc.
                   (SDGR) | 
               
                   SHAW DAVID E
                    (10% owner) | 
               141072 (S) $75.36 | 
               2021-06-14 | 
           | 
                   Synaptogenix, Inc.
                   (SNPX) | 
               
                   Silverman Joshua
                    (Director) | 
               10000 (B) $8.30 | 
               2021-06-14 | 
           | 
                   Evofem Biosciences, Inc.
                   (EVFM) | 
               
                   Barrans Russell
                    (Chief Commercial Officer) | 
               18180 (B) $1.14 | 
               2021-06-11 | 
           | 
                   Trinseo S.A.
                   (TSE) | 
               
                   De Leener Pierre-Marie
                    (Director) | 
               9339 (S) $65.00 | 
               2021-06-11 | 
           | 
                   ESTEE LAUDER COMPANIES INC
                   (EL) | 
               
                   ZINTERHOFER AERIN LAUDER TRUST U/A/D 4/24/00
                    (10% owner) | 
               97971 (S) $300.87 | 
               2021-06-11 | 
           | 
                   Eledon Pharmaceuticals, Inc.
                   (ELDN) | 
               
                   Little Paul Sean
                    (CHIEF FINANCIAL OFFICER) | 
               10000 (B) $8.87 | 
               2021-06-11 | 
           | 
                   CYTOKINETICS INC
                   (CYTK) | 
               
                   Malik Fady Ibraham
                    (EVP Research & Development) | 
               2000 (S) $21.48 | 
               2021-06-10 | 
           | 
                   Viking Therapeutics, Inc.
                   (VKTX) | 
               
                   FOEHR MATTHEW W
                    (Director) | 
               20000 (B) $5.69 | 
               2021-06-10 | 
           | 
                   ELI LILLY & Co
                   (LLY) | 
               
                   LILLY ENDOWMENT INC
                    (10% owner) | 
               240000 (S) $234.05 | 
               2021-06-10 | 
           | 
                   Y-mAbs Therapeutics, Inc.
                   (YMAB) | 
               
                   WG Biotech ApS
                    (See remarks) | 
               11229 (S) $36.15 | 
               2021-06-10 | 
           | 
                   Y-mAbs Therapeutics, Inc.
                   (YMAB) | 
               
                   Wedell-Wedellsborg Johan
                    (Director) | 
               11229 (S) $36.15 | 
               2021-06-10 | 
           | 
                   Emmaus Life Sciences, Inc.
                   (EMMA) | 
               
                   Niihara Yutaka
                    (Chairman and CEO) | 
               3216 (B) $1.61 | 
               2021-06-10 | 
           | 
                   Inmune Bio, Inc.
                   (INMB) | 
               
                   Schroeder Timothy j
                    (Director) | 
               10000 (S) $17.01 | 
               2021-06-10 | 
           | 
                   NEUROCRINE BIOSCIENCES INC
                   (NBIX) | 
               
                   LYONS GARY A
                    (Director) | 
               10000 (S) $100.27 | 
               2021-06-10 | 
           | 
                   Royalty Pharma plc
                   (RPRX) | 
               
                   Lloyd George W.
                    (EVP, Investments & GC) | 
               70000 (S) $46.47 | 
               2021-06-10 | 
           | 
                   Protara Therapeutics, Inc.
                   (TARA) | 
               
                   Olivo Martin Sebastian
                    (Chief Medical Officer) | 
               9893 (B) $10.11 | 
               2021-06-10 | 
           | 
                   ALX ONCOLOGY HOLDINGS INC
                   (ALXO) | 
               
                   Randolph Sophia
                    (Chief Medical Officer) | 
               7387 (S) $60.74 | 
               2021-06-10 | 
           | 
                   Recro Pharma, Inc.
                   (REPH) | 
               
                   AWM Investment Company, Inc.
                    (10% owner) | 
               466667 (S) $2.20 | 
               2021-06-10 | 
           | 
                   Alto Ingredients, Inc.
                   (ALTO) | 
               
                   NATHAN GILBERT E
                    (Director) | 
               40000 (B) $6.11 | 
               2021-06-10 | 
           | 
                   Cerecor Inc.
                   (CERC) | 
               
                   Harrell James Archie Jr
                    (Chief Commercial Officer) | 
               7493 (B) $2.28 | 
               2021-06-10 | 
           | 
                   Cerecor Inc.
                   (CERC) | 
               
                   Greenway Schond L.
                    (CFO) | 
               652 (B) $2.68 | 
               2021-06-10 | 
           | 
                   Sonnet BioTherapeutics Holdings, Inc.
                   (SONN) | 
               
                   Mohan Pankaj
                    (Chairman, President and CEO) | 
               32000 (B) $1.55 | 
               2021-06-09 | 
           | 
                   AbCellera Biologics Inc.
                   (ABCL) | 
               
                   Falconer Ester
                    (Chief Technology Officer) | 
               1000000 (S) $25.50 | 
               2021-06-09 | 
           | 
                   AbCellera Biologics Inc.
                   (ABCL) | 
               
                   Hansen Carl L. G.
                    (Chief Executive Officer) | 
               6000000 (S) $24.77 | 
               2021-06-09 | 
           | 
                   AbCellera Biologics Inc.
                   (ABCL) | 
               
                   Thermopylae Holdings Ltd.
                    (10% owner) | 
               5598420 (S) $24.03 | 
               2021-06-09 | 
           | 
                   Organogenesis Holdings Inc.
                   (ORGO) | 
               
                   Albert Erani Family Trust dated 12/29/2012
                    (10% owner) | 
               150000 (S) $15.31 | 
               2021-06-09 | 
           | 
                   Coherus BioSciences, Inc.
                   (CHRS) | 
               
                   Stilwell McDavid
                    (Chief Financial Officer) | 
               3700 (B) $13.42 | 
               2021-06-09 | 
           | 
                   ELI LILLY & Co
                   (LLY) | 
               
                   LILLY ENDOWMENT INC
                    (10% owner) | 
               220000 (S) $225.21 | 
               2021-06-09 | 
           | 
                   Eledon Pharmaceuticals, Inc.
                   (ELDN) | 
               
                   Gros David-Alexandre C
                    (Chief Executive Officer) | 
               3000 (B) $8.01 | 
               2021-06-09 | 
           | 
                   Repare Therapeutics Inc.
                   (RPTX) | 
               
                   Segal Lloyd Mitchell
                    (President and CEO) | 
               1576 (S) $35.00 | 
               2021-06-09 | 
           | 
                   ALNYLAM PHARMACEUTICALS, INC.
                   (ALNY) | 
               
                   KEATING LAURIE
                    (EVP, Chief Legal Officer) | 
               1734 (S) $154.00 | 
               2021-06-09 | 
           | 
                   BIO-TECHNE Corp
                   (TECH) | 
               
                   Kelderman Kim
                    (Pres. Diagnostics & Genom) | 
               811 (S) $433.00 | 
               2021-06-09 | 
           | 
                   KalVista Pharmaceuticals, Inc.
                   (KALV) | 
               
                   Crockett Thomas Andrew
                    (CEO) | 
               8933 (S) $30.05 | 
               2021-06-09 | 
           | 
                   Phathom Pharmaceuticals, Inc.
                   (PHAT) | 
               
                   TAKEDA PHARMACEUTICAL CO LTD
                    (10% owner) | 
               3293 (S) $35.21 | 
               2021-06-09 | 
           | 
                   Renewable Energy Group, Inc.
                   (REGI) | 
               
                   Stroburg Jeffrey
                    (Director) | 
               9786 (S) $70.00 | 
               2021-06-09 | 
           | 
                   Applied Therapeutics Inc.
                   (APLT) | 
               
                   Silberstein Charles
                    (Chief Financial Officer) | 
               5047 (S) $21.42 | 
               2021-06-08 | 
           | 
                   Tricida, Inc.
                   (TCDA) | 
               
                   COUFAL SANDRA I
                    (10% owner) | 
               5000 (S) $4.78 | 
               2021-06-08 | 
           | 
                   TYME TECHNOLOGIES, INC.
                   (TYME) | 
               
                   Hoffman Steve
                    (Chief Science Officer) | 
               82500 (S) $1.58 | 
               2021-06-08 | 
           | 
                   Pacira BioSciences, Inc.
                   (PCRX) | 
               
                   Manning Donald C.
                    (Chief Medical Officer) | 
               2600 (S) $61.14 | 
               2021-06-08 | 
           | 
                   Reneo Pharmaceuticals, Inc.
                   (RPHM) | 
               
                   Muralidhar Bali
                    (Director) | 
               16605 (B) $9.50 | 
               2021-06-08 | 
           | 
                   Timber Pharmaceuticals, Inc.
                   (TMBR) | 
               
                   TardiMed Sciences LLC
                    (10% owner) | 
               587250 (S) $1.27 | 
               2021-06-08 | 
           | 
                   Y-mAbs Therapeutics, Inc.
                   (YMAB) | 
               
                   Wedell-Wedellsborg Johan
                    (Director) | 
               150000 (S) $35.73 | 
               2021-06-08 | 
           | 
                   Akebia Therapeutics, Inc.
                   (AKBA) | 
               
                   GILMAN STEVEN C
                    (Other) | 
               4567 (S) $3.32 | 
               2021-06-07 | 
           | 
                   PRECIGEN, INC.
                   (PGEN) | 
               
                   Ares Trading S.A.
                    (10% owner) | 
               429489 (S) $7.06 | 
               2021-06-07 | 
           | 
                   HUMANIGEN, INC
                   (HGEN) | 
               
                   Chappell Dale
                    (Chief Scientific Officer) | 
               80636 (S) $19.08 | 
               2021-06-07 | 
           | 
                   BeiGene, Ltd.
                   (BGNE) | 
               
                   Wang Lai
                    (Global Head of R&D) | 
               656 (S) $354.26 | 
               2021-06-07 | 
           | 
                   BeiGene, Ltd.
                   (BGNE) | 
               
                   Wu Xiaobin
                    (President, COO & GM China) | 
               3398 (S) $352.47 | 
               2021-06-07 | 
           | 
                   Ocugen, Inc.
                   (OCGN) | 
               
                   Castillo Kirsten
                    (Director) | 
               10000 (S) $10.00 | 
               2021-06-07 | 
           | 
                   PMV Pharmaceuticals, Inc.
                   (PMVP) | 
               
                   Euclidean Capital LLC
                    (10% owner) | 
               62445 (S) $33.50 | 
               2021-06-07 | 
           | 
                   DYADIC INTERNATIONAL INC
                   (DYAI) | 
               
                   EMALFARB MARK A
                    (President and CEO) | 
               97000 (S) $3.83 | 
               2021-06-07 | 
           | 
                   Green Plains Inc.
                   (GPRE) | 
               
                   Peterson Brian
                    (Director) | 
               35000 (S) $32.48 | 
               2021-06-07 | 
           | 
                   MeiraGTx Holdings plc
                   (MGTX) | 
               
                   Naylor Stuart
                    (Chief Development Officer) | 
               6082 (S) $15.02 | 
               2021-06-07 | 
           | 
                   Phathom Pharmaceuticals, Inc.
                   (PHAT) | 
               
                   TAKEDA PHARMACEUTICAL CO LTD
                    (10% owner) | 
               2364 (S) $35.02 | 
               2021-06-07 | 
           | 
                   Y-mAbs Therapeutics, Inc.
                   (YMAB) | 
               
                   Wedell-Wedellsborg Johan
                    (Director) | 
               72400 (S) $34.15 | 
               2021-06-07 | 
           | 
                   Y-mAbs Therapeutics, Inc.
                   (YMAB) | 
               
                   Kruse Bo
                    (EVP, CFO, Secretary & Treas.) | 
               4000 (S) $33.48 | 
               2021-06-04 | 
           | 
                   Verrica Pharmaceuticals Inc.
                   (VRCA) | 
               
                   DAVIS A BRIAN
                    (Chief Financial Officer) | 
               5000 (B) $9.89 | 
               2021-06-04 | 
           | 
                   HESKA CORP
                   (HSKA) | 
               
                   Wisnewski Nancy
                    (Chief Operating Officer) | 
               5000 (S) $197.85 | 
               2021-06-04 | 
           | 
                   Zosano Pharma Corp
                   (ZSAN) | 
               
                   KELLERMAN DONALD J
                    (VP, Clinical Dev & Med Affairs) | 
               1709 (S) $0.81 | 
               2021-06-04 | 
           | 
                   Zosano Pharma Corp
                   (ZSAN) | 
               
                   Lewis Hayley
                    (See Remarks) | 
               1709 (S) $0.81 | 
               2021-06-04 | 
           | 
                   Zosano Pharma Corp
                   (ZSAN) | 
               
                   Lo Steven
                    (Chief Executive Officer) | 
               13158 (S) $0.81 | 
               2021-06-04 | 
           | 
                   Zosano Pharma Corp
                   (ZSAN) | 
               
                   Matthews Christine
                    (Chief Financial Officer) | 
               1709 (S) $0.81 | 
               2021-06-04 | 
           | 
                   Neoleukin Therapeutics, Inc.
                   (NLTX) | 
               
                   Walkey Carl
                    (Senior Vice President) | 
               600 (S) $10.00 | 
               2021-06-04 | 
           | 
                   Verrica Pharmaceuticals Inc.
                   (VRCA) | 
               
                   White Ted
                    (President and CEO) | 
               4000 (B) $9.95 | 
               2021-06-04 | 
           | 
                   BODY & MIND INC.
                   (BAMM) | 
               
                   AUSTRALIS CAPITAL INC
                    (10% owner) | 
               72000 (S) $0.35 | 
               2021-06-04 | 
           | 
                   Eton Pharmaceuticals, Inc.
                   (ETON) | 
               
                   BRYNJELSEN SEAN
                    (President & CEO) | 
               5000 (B) $5.96 | 
               2021-06-03 | 
           | 
                   Aclaris Therapeutics, Inc.
                   (ACRS) | 
               
                   Ali-Jackson Kamil
                    (Chief Legal Officer) | 
               9492 (S) $21.96 | 
               2021-06-03 | 
           | 
                   Moderna, Inc.
                   (MRNA) | 
               
                   Bancel Stephane
                    (Chief Executive Officer) | 
               10000 (S) $188.89 | 
               2021-06-03 | 
           | 
                   Trinseo S.A.
                   (TSE) | 
               
                   Johnson KLynne
                    (Director) | 
               2576 (S) $66.92 | 
               2021-06-03 | 
           | 
                   Kraig Biocraft Laboratories, Inc
                   (KBLB) | 
               
                   Thompson Kimberly Kraig
                    (CEO & CFO) | 
               35585 (S) $0.00 | 
               2021-06-03 | 
           | 
                   Cyclerion Therapeutics, Inc.
                   (CYCN) | 
               
                   MCGUIRE TERRANCE
                    (Director) | 
               96153 (B) $3.12 | 
               2021-06-03 | 
           | 
                   Neoleukin Therapeutics, Inc.
                   (NLTX) | 
               
                   DRACHMAN JONATHAN G
                    (President and CEO) | 
               50000 (B) $9.54 | 
               2021-06-03 |