| 
                   Revolution Medicines, Inc.
                   (RVMD) | 
               
                   Exter Neil
                    (Director) | 
                | 
               2021-06-03 | 
           | 
                   Y-mAbs Therapeutics, Inc.
                   (YMAB) | 
               
                   WG Biotech ApS
                    (10% owner) | 
               34507 (S) $33.61 | 
               2021-06-03 | 
           | 
                   AMARIN CORP PLC\UK
                   (AMRN) | 
               
                   STACK DAVID M
                    (Director) | 
               15000 (B) $4.58 | 
               2021-06-03 | 
           | 
                   Adicet Bio, Inc.
                   (ACET) | 
               
                   Schor Chen
                    (President & CEO) | 
               16466 (S) $12.06 | 
               2021-06-03 | 
           | 
                   Allakos Inc.
                   (ALLK) | 
               
                   Tomasi Adam
                    (President and COO) | 
               4906 (S) $91.50 | 
               2021-06-03 | 
           | 
                   PRECIGEN, INC.
                   (PGEN) | 
               
                   Ares Trading S.A.
                    (10% owner) | 
               160677 (S) $6.62 | 
               2021-06-03 | 
           | 
                   Jaguar Health, Inc.
                   (JAGX) | 
               
                   BOCHNOWSKI JAMES J
                    (Director) | 
               444 (S) $1.75 | 
               2021-06-03 | 
           | 
                   Cyclerion Therapeutics, Inc.
                   (CYCN) | 
               
                   Slate Path Capital LP
                    (10% owner) | 
               961538 (B) $3.12 | 
               2021-06-03 | 
           | 
                   Repare Therapeutics Inc.
                   (RPTX) | 
               
                   Foley Todd
                    (Director) | 
               25622 (S) $31.66 | 
               2021-06-03 | 
           | 
                   Repare Therapeutics Inc.
                   (RPTX) | 
               
                   GADICKE ANSBERT
                    (10% owner) | 
               58149 (S) $31.66 | 
               2021-06-03 | 
           | 
                   Kindred Biosciences, Inc.
                   (KIN) | 
               
                   Park West Asset Management LLC
                    (10% owner) | 
               414983 (S) $6.87 | 
               2021-06-03 | 
           | 
                   Vir Biotechnology, Inc.
                   (VIR) | 
               
                   MORE ROBERT J
                    (Director) | 
               11670 (S) $44.56 | 
               2021-06-03 | 
           | 
                   Tilray, Inc.
                   (TLRY) | 
               
                   Meiers James R.
                    (Head of Canada) | 
               23826 (S) $19.64 | 
               2021-06-03 | 
           | 
                   Renewable Energy Group, Inc.
                   (REGI) | 
               
                   Sorrells Christopher D.
                    (Director) | 
               5000 (S) $70.00 | 
               2021-06-03 | 
           | 
                   Repare Therapeutics Inc.
                   (RPTX) | 
               
                   Segal Lloyd Mitchell
                    (President and CEO) | 
               41000 (S) $31.25 | 
               2021-06-03 | 
           | 
                   Y-mAbs Therapeutics, Inc.
                   (YMAB) | 
               
                   Wedell-Wedellsborg Johan
                    (Director) | 
               34507 (S) $33.61 | 
               2021-06-03 | 
           | 
                   X4 Pharmaceuticals, Inc
                   (XFOR) | 
               
                   Ragan Paula
                    (President and CEO) | 
               2400 (S) $9.50 | 
               2021-06-02 | 
           | 
                   Alector, Inc.
                   (ALEC) | 
               
                   Yu Calvin
                    (Vice President, Finance) | 
               1844 (S) $17.77 | 
               2021-06-02 | 
           | 
                   Renewable Energy Group, Inc.
                   (REGI) | 
               
                   Stone Chad
                    (SVP, Commercial Performance) | 
               5000 (S) $68.00 | 
               2021-06-02 | 
           | 
                   Sigilon Therapeutics, Inc.
                   (SGTX) | 
               
                   ANDERSON DANIEL GRIFFITH
                    (Other) | 
               200000 (S) $10.00 | 
               2021-06-02 | 
           | 
                   PUMA BIOTECHNOLOGY, INC.
                   (PBYI) | 
               
                   AUERBACH ALAN H
                    (PRESIDENT AND CEO) | 
               1757 (S) $10.74 | 
               2021-06-02 | 
           | 
                   HUMANIGEN, INC
                   (HGEN) | 
               
                   Chappell Dale
                    (Chief Scientific Officer) | 
               394364 (S) $18.61 | 
               2021-06-02 | 
           | 
                   Centessa Pharmaceuticals plc
                   (CNTA) | 
               
                   Bush Tia L
                    (Chief Quality Officer) | 
               3000 (B) $20.00 | 
               2021-06-02 | 
           | 
                   Centessa Pharmaceuticals plc
                   (CNTA) | 
               
                   CHAO DAVID M
                    (Chief Administrative Officer) | 
               500 (B) $20.00 | 
               2021-06-02 | 
           | 
                   Centessa Pharmaceuticals plc
                   (CNTA) | 
               
                   Weinhoff Gregory M
                    (Chief Financial Officer) | 
               10000 (B) $20.00 | 
               2021-06-02 | 
           | 
                   Centessa Pharmaceuticals plc
                   (CNTA) | 
               
                   Thorell Marella
                    (Chief Accounting Officer) | 
               1000 (B) $20.00 | 
               2021-06-02 | 
           | 
                   Centessa Pharmaceuticals plc
                   (CNTA) | 
               
                   Templeman Thomas
                    (Chief Technology Officer) | 
               250 (B) $20.00 | 
               2021-06-02 | 
           | 
                   PUMA BIOTECHNOLOGY, INC.
                   (PBYI) | 
               
                   HUNT DOUGLAS M
                    (See Remarks) | 
               416 (S) $10.77 | 
               2021-06-02 | 
           | 
                   Vallon Pharmaceuticals, Inc.
                   (VLON) | 
               
                   Kelly Leanne M.
                    (Chief Financial Officer) | 
               6250 (B) $4.04 | 
               2021-06-02 | 
           | 
                   Phathom Pharmaceuticals, Inc.
                   (PHAT) | 
               
                   TAKEDA PHARMACEUTICAL CO LTD
                    (10% owner) | 
               4300 (S) $35.18 | 
               2021-06-02 | 
           | 
                   ESTEE LAUDER COMPANIES INC
                   (EL) | 
               
                   Freda Fabrizio
                    (President and CEO) | 
               32209 (S) $308.00 | 
               2021-06-01 | 
           | 
                   Zentalis Pharmaceuticals, Inc.
                   (ZNTL) | 
               
                   Epperly Melissa B,
                    (Chief Financial Officer) | 
               3083 (S) $54.45 | 
               2021-06-01 | 
           | 
                   RAPT Therapeutics, Inc.
                   (RAPT) | 
               
                   HO WILLIAM
                    (Chief Medical Officer) | 
               1000 (S) $19.50 | 
               2021-06-01 | 
           | 
                   AMICUS THERAPEUTICS, INC.
                   (FOLD) | 
               
                   WHITMAN BURKE W
                    (Director) | 
               1500 (B) $9.24 | 
               2021-06-01 | 
           | 
                   Aditx Therapeutics, Inc.
                   (ADTX) | 
               
                   Albanna Amro A.
                    (CHIEF EXECUTIVE OFFICER) | 
               3400 (B) $2.92 | 
               2021-06-01 | 
           | 
                   Akero Therapeutics, Inc.
                   (AKRO) | 
               
                   Young Jonathan
                    (Chief Operating Officer) | 
               3055 (S) $26.24 | 
               2021-06-01 | 
           | 
                   REX AMERICAN RESOURCES Corp
                   (REX) | 
               
                   BRUGGEMAN DOUGLAS
                    (CFO, VP-Finance, Treasurer) | 
               1000 (S) $98.20 | 
               2021-06-01 | 
           | 
                   Trinseo S.A.
                   (TSE) | 
               
                   M&G INVESTMENT MANAGEMENT LTD
                    (10% owner) | 
               3000 (S) $66.50 | 
               2021-06-01 | 
           | 
                   Zentalis Pharmaceuticals, Inc.
                   (ZNTL) | 
               
                   SUN ANTHONY Y
                    (President & CEO) | 
               26794 (S) $54.33 | 
               2021-06-01 | 
           | 
                   IDERA PHARMACEUTICALS, INC.
                   (IDRA) | 
               
                   DOUGHERTY MICHAEL R
                    (Other) | 
               85000 (B) $1.19 | 
               2021-06-01 | 
           | 
                   Denali Therapeutics Inc.
                   (DNLI) | 
               
                   Watts Ryan J.
                    (President and CEO) | 
               18333 (S) $62.33 | 
               2021-06-01 | 
           | 
                   Travere Therapeutics, Inc.
                   (TVTX) | 
               
                   Dube Eric M
                    (Chief Executive Officer) | 
               9562 (S) $14.62 | 
               2021-06-01 | 
           | 
                   Emmaus Life Sciences, Inc.
                   (EMMA) | 
               
                   Niihara Yutaka
                    (Chairman and CEO) | 
               2065 (B) $1.62 | 
               2021-06-01 | 
           | 
                   KalVista Pharmaceuticals, Inc.
                   (KALV) | 
               
                   Feener Edward P.
                    (Chief Scientific Officer) | 
               34000 (S) $26.85 | 
               2021-06-01 | 
           | 
                   GALECTIN THERAPEUTICS INC
                   (GALT) | 
               
                   10X Fund, L.P.
                    (10% owner) | 
               10000 (S) $3.91 | 
               2021-06-01 | 
           | 
                   Akero Therapeutics, Inc.
                   (AKRO) | 
               
                   Bitterman Kevin
                    (Director) | 
               17489 (S) $26.28 | 
               2021-06-01 | 
           | 
                   Galera Therapeutics, Inc.
                   (GRTX) | 
               
                   Alleva Lawrence M
                    (Director) | 
               4045 (B) $8.59 | 
               2021-06-01 | 
           | 
                   Mersana Therapeutics, Inc.
                   (MRSN) | 
               
                   Alleva Lawrence M
                    (Director) | 
               1035 (B) $14.38 | 
               2021-06-01 | 
           | 
                   PRECIGEN, INC.
                   (PGEN) | 
               
                   Ares Trading S.A.
                    (10% owner) | 
               228000 (S) $6.62 | 
               2021-06-01 | 
           | 
                   Moderna, Inc.
                   (MRNA) | 
               
                   Bancel Stephane
                    (Chief Executive Officer) | 
               22062 (S) $157.32 | 
               2021-06-01 | 
           | 
                   CF Industries Holdings, Inc.
                   (CF) | 
               
                   Will W Anthony
                    (President & CEO) | 
               40001 (S) $55.01 | 
               2021-06-01 | 
           | 
                   Shattuck Labs, Inc.
                   (STTK) | 
               
                   Hornblower Josiah
                    (Director) | 
               17824 (S) $27.45 | 
               2021-06-01 | 
           | 
                   Huntsman CORP
                   (HUN) | 
               
                   Wright Randy W.
                    (VP and Controller) | 
               42671 (S) $28.99 | 
               2021-06-01 | 
           | 
                   Morphic Holding, Inc.
                   (MORF) | 
               
                   Linde Peter
                    (Chief Medical Officer) | 
               6000 (S) $50.01 | 
               2021-06-01 | 
           | 
                   ZOGENIX, INC.
                   (ZGNX) | 
               
                   TANNENBAUM RENEE P
                    (Director) | 
               5000 (B) $17.05 | 
               2021-06-01 | 
           | 
                   Trulieve Cannabis Corp.
                   (TRUL) | 
               
                   D'Amico Alex
                    (Chief Financial Officer) | 
               660 (B) $38.00 | 
               2021-05-28 | 
           | 
                   FULLER H B CO
                   (FUL) | 
               
                   Owens James
                    (President and CEO) | 
               5000 (S) $67.91 | 
               2021-05-28 | 
           | 
                   Repare Therapeutics Inc.
                   (RPTX) | 
               
                   Foley Todd
                    (Director) | 
               16786 (S) $32.36 | 
               2021-05-28 | 
           | 
                   Galera Therapeutics, Inc.
                   (GRTX) | 
               
                   West Linda
                    (Director) | 
               20000 (B) $8.64 | 
               2021-05-28 | 
           | 
                   ARDELYX, INC.
                   (ARDX) | 
               
                   Rosenbaum David P.
                    (Chief Development Officer) | 
               3062 (S) $7.22 | 
               2021-05-28 | 
           | 
                   Reneo Pharmaceuticals, Inc.
                   (RPHM) | 
               
                   Muralidhar Bali
                    (Director) | 
               14 (B) $9.50 | 
               2021-05-28 | 
           | 
                   Phathom Pharmaceuticals, Inc.
                   (PHAT) | 
               
                   TAKEDA PHARMACEUTICAL CO LTD
                    (10% owner) | 
               20116 (S) $36.21 | 
               2021-05-28 | 
           | 
                   Timber Pharmaceuticals, Inc.
                   (TMBR) | 
               
                   TardiMed Sciences LLC
                    (10% owner) | 
               66285 (S) $1.26 | 
               2021-05-28 | 
           | 
                   Y-mAbs Therapeutics, Inc.
                   (YMAB) | 
               
                   Wedell-Wedellsborg Johan
                    (Director) | 
               31864 (S) $35.96 | 
               2021-05-28 | 
           | 
                   ACHIEVE LIFE SCIENCES, INC.
                   (ACHV) | 
               
                   Bencich John
                    (CEO) | 
               6000 (B) $7.00 | 
               2021-05-27 | 
           | 
                   KEMPHARM, INC
                   (KMPH) | 
               
                   Clifton R. LaDuane
                    (CFO, Secretary & Treasurer) | 
               150 (B) $9.85 | 
               2021-05-27 | 
           | 
                   Oric Pharmaceuticals, Inc.
                   (ORIC) | 
               
                   Chacko Jacob
                    (President and CEO) | 
               400 (S) $25.07 | 
               2021-05-27 | 
           | 
                   Intra-Cellular Therapies, Inc.
                   (ITCI) | 
               
                   Alafi Christopher D
                    (Director) | 
               47325 (S) $40.06 | 
               2021-05-27 | 
           | 
                   Organogenesis Holdings Inc.
                   (ORGO) | 
               
                   NUSSDORF GLENN H
                    (10% owner) | 
               3887500 (S) $16.40 | 
               2021-05-27 | 
           | 
                   Organogenesis Holdings Inc.
                   (ORGO) | 
               
                   Ades Alan A.
                    (10% owner) | 
               3887500 (S) $16.40 | 
               2021-05-27 | 
           | 
                   EYENOVIA, INC.
                   (EYEN) | 
               
                   Rowe Michael M
                    (Chief Operating Officer) | 
               1400 (B) $4.71 | 
               2021-05-27 | 
           | 
                   Neoleukin Therapeutics, Inc.
                   (NLTX) | 
               
                   Walkey Carl
                    (Senior Vice President) | 
               600 (S) $10.00 | 
               2021-05-26 | 
           | 
                   Green Plains Inc.
                   (GPRE) | 
               
                   CROWLEY JAMES F
                    (Director) | 
               13000 (S) $30.95 | 
               2021-05-26 | 
           | 
                   Applied Therapeutics Inc.
                   (APLT) | 
               
                   Hansard Adam
                    (Chief Commercial Officer) | 
               2894 (S) $18.35 | 
               2021-05-26 | 
           | 
                   PRECIGEN, INC.
                   (PGEN) | 
               
                   Ares Trading S.A.
                    (10% owner) | 
               335147 (S) $6.70 | 
               2021-05-26 | 
           | 
                   Bausch Health Companies Inc.
                   (BHC) | 
               
                   WECHSLER AMY B
                    (Director) | 
               11037 (S) $31.79 | 
               2021-05-26 | 
           | 
                   Shattuck Labs, Inc.
                   (STTK) | 
               
                   Hornblower Josiah
                    (Director) | 
               18990 (S) $26.10 | 
               2021-05-26 | 
           | 
                   COTY INC.
                   (COTY) | 
               
                   Cottage Holdco B.V.
                    (10% owner) | 
               245700 (B) $11.78 | 
               2021-05-26 | 
           | 
                   Moderna, Inc.
                   (MRNA) | 
               
                   Bancel Stephane
                    (Chief Executive Officer) | 
               21000 (S) $114.30 | 
               2021-05-26 | 
           | 
                   IGM Biosciences, Inc.
                   (IGMS) | 
               
                   Chen Daniel ShinYu
                    (Chief Medical Officer) | 
               444 (S) $70.00 | 
               2021-05-26 | 
           | 
                   Denali Therapeutics Inc.
                   (DNLI) | 
               
                   SATO VICKI L
                    (Director) | 
               1666 (S) $65.83 | 
               2021-05-26 | 
           | 
                   Emmaus Life Sciences, Inc.
                   (EMMA) | 
               
                   LEE WILLIS C
                    (Vice Chairman & COO) | 
               8600 (B) $1.56 | 
               2021-05-26 | 
           | 
                   Emmaus Life Sciences, Inc.
                   (EMMA) | 
               
                   Niihara Yutaka
                    (Chairman and CEO) | 
               17200 (B) $1.57 | 
               2021-05-26 | 
           | 
                   Equillium, Inc.
                   (EQ) | 
               
                   Keyes Jason A
                    (Chief Financial Officer) | 
               5000 (S) $6.50 | 
               2021-05-26 | 
           | 
                   Reneo Pharmaceuticals, Inc.
                   (RPHM) | 
               
                   Muralidhar Bali
                    (Director) | 
               7035 (B) $9.32 | 
               2021-05-26 | 
           | 
                   Phathom Pharmaceuticals, Inc.
                   (PHAT) | 
               
                   TAKEDA PHARMACEUTICAL CO LTD
                    (10% owner) | 
               20811 (S) $36.98 | 
               2021-05-26 | 
           | 
                   Eton Pharmaceuticals, Inc.
                   (ETON) | 
               
                   Opaleye Management Inc.
                    (10% owner) | 
               105000 (S) $8.07 | 
               2021-05-26 | 
           | 
                   Aditx Therapeutics, Inc.
                   (ADTX) | 
               
                   Pankovcin Corinne
                    (CHIEF FINANCIAL OFFICER) | 
               4220 (B) $2.56 | 
               2021-05-25 | 
           | 
                   OPKO HEALTH, INC.
                   (OPK) | 
               
                   FROST PHILLIP MD ET AL
                    (CEO & Chairman) | 
               400000 (B) $3.64 | 
               2021-05-25 | 
           | 
                   Immunome Inc.
                   (IMNM) | 
               
                   Sarma Purnanand D
                    (President and CEO) | 
               10500 (B) $18.41 | 
               2021-05-25 | 
           | 
                   BIO-TECHNE Corp
                   (TECH) | 
               
                   Kelderman Kim
                    (Pres. Diagnostics & Genom) | 
               845 (S) $424.00 | 
               2021-05-25 | 
           | 
                   Tricida, Inc.
                   (TCDA) | 
               
                   COUFAL SANDRA I
                    (10% owner) | 
               5000 (S) $4.56 | 
               2021-05-25 | 
           | 
                   DuPont de Nemours, Inc.
                   (DD) | 
               
                   Kemp Jon D.
                    (President, E&I) | 
               3500 (S) $84.38 | 
               2021-05-25 | 
           | 
                   Emergent BioSolutions Inc.
                   (EBS) | 
               
                   Zoon Kathryn C
                    (Director) | 
               3139 (S) $56.48 | 
               2021-05-25 | 
           | 
                   Repare Therapeutics Inc.
                   (RPTX) | 
               
                   Foley Todd
                    (Director) | 
               16989 (S) $33.03 | 
               2021-05-25 | 
           | 
                   Tronox Holdings plc
                   (TROX) | 
               
                   Nkosi Sipho Abednego
                    (Director) | 
               89000 (S) $23.14 | 
               2021-05-25 | 
           | 
                   Aditx Therapeutics, Inc.
                   (ADTX) | 
               
                   Shabahang Shahrokh
                    (CHIEF INNOVATION OFFICER) | 
               602 (B) $2.49 | 
               2021-05-25 | 
           | 
                   Clene Inc.
                   (CLNN) | 
               
                   MATLIN DAVID J
                    (Other) | 
               207684 (B) $9.63 | 
               2021-05-24 | 
           | 
                   ELI LILLY & Co
                   (LLY) | 
               
                   LILLY ENDOWMENT INC
                    (10% owner) | 
               7329 (S) $202.45 | 
               2021-05-24 | 
           | 
                   Kraig Biocraft Laboratories, Inc
                   (KBLB) | 
               
                   Thompson Kimberly Kraig
                    (CEO & CFO) | 
               15000 (S) $0.00 | 
               2021-05-24 |