Insider Trading activities at Spero Therapeutics, Inc. (SPRO)

Insider trading activities (stock purchases, sales, and option exercises) reported by insiders of Spero Therapeutics, Inc. (SPRO) since 2017 are shown in Table 1 and Table 2. Table 1 shows the monthly insider trading data of Spero Therapeutics, Inc.. Table 2 shows the detailed insider transactions. This company's CIK number is 1701108.

Total stock buying since 2017: $43,885,930.
Total stock sales since 2017: $17,151,400.
Total stock option exercises since 2017: $345,123.


13 insiders reported insider trading activities at Spero Therapeutics, Inc. (SPRO):
Insider trading activities of Rajavelu Esther
Insider trading activities of Glaxosmithkline Plc
Insider trading activities of Joseph Tamara L
Insider trading activities of Shukla Sath
Insider trading activities of Goyal Vikas
Insider trading activities of Sendek Joel
Insider trading activities of Hamed Kamal
Insider trading activities of Formela Jean Francois
Insider trading activities of Mahadevia Ankit
Insider trading activities of Aquilo Capital, L.p.
Insider trading activities of Larkin Cristina
Insider trading activities of Keutzer Timothy
Insider trading activities of Breum Casper

Table 1. Yearly summary of insider stock purchases, sales, and option exercises at Spero Therapeutics, Inc. (SPRO).
Insider Buying Insider Sales Option Exercises
Year Shares Value Shares Value Shares Value
2025 0 $0 310,045 $251,669 0 $0
2024 0 $0 313,660 $428,381 0 $0
2023 0 $0 86,839 $126,202 0 $0
2022 357,050 $3,574,670 1,901,796 $4,279,041 0 $0
2021 1,098,033 $18,220,288 111,000 $2,083,881 8,000 $47,200
2020 0 $0 604,753 $9,794,732 39,820 $234,935
2018 80,000 $1,000,000 10,676 $187,494 10,676 $62,988
2017 1,506,498 $21,090,972 0 $0 0 $0

Table 2. Monthly summary of insider trading at Spero Therapeutics, Inc. (SPRO).
Trading Period Insider Buying Insider Sales Option Exercises
year-month Shares Value Shares Value Shares Value
2025-08 0 $0 8,267 $16,285 0 $0
2025-02 0 $0 301,778 $235,384 0 $0
2024-11 0 $0 40,596 $53,007 0 $0
2024-08 0 $0 43,323 $57,334 0 $0
2024-02 0 $0 229,741 $318,040 0 $0
2023-09 0 $0 39,496 $50,159 0 $0
2023-08 0 $0 18,765 $23,809 0 $0
2023-02 0 $0 28,578 $52,234 0 $0
2022-09 0 $0 1,901,796 $4,279,041 0 $0
2022-04 39,727 $207,970 0 $0 0 $0
2022-03 73,708 $620,197 0 $0 0 $0
2022-02 59,661 $564,253 0 $0 0 $0
2022-01 183,954 $2,182,250 0 $0 0 $0
2021-12 250,493 $3,862,893 8,000 $116,664 8,000 $47,200
2021-10 150,000 $2,630,250 0 $0 0 $0
2021-09 205,658 $3,827,551 0 $0 0 $0
2021-08 491,882 $7,899,594 0 $0 0 $0
2021-02 0 $0 103,000 $1,967,217 0 $0
2020-12 0 $0 276,933 $5,209,287 12,000 $70,800
2020-11 0 $0 309,507 $4,323,867 9,507 $56,091
2020-10 0 $0 14,492 $206,999 14,492 $85,502
2020-09 0 $0 774 $11,029 774 $4,566
2020-07 0 $0 3,047 $43,550 3,047 $17,976
2018-07 80,000 $1,000,000 10,676 $187,494 10,676 $62,988

Table 3. Detailed insider trading at Spero Therapeutics, Inc. (SPRO)
  Trade Date   Insider Name Trade Type     Shares       Price ($)   Value ($)
2025-08-28 Keutzer Timothy (Chief Operating Officer) Sale 1,695 1.97 3,339
2025-08-28 Mahadevia Ankit Sale 6,572 1.97 12,946
2025-02-05 Rajavelu Esther (CFO & CBO) Sale 20,689 .78 16,137
2025-02-05 Keutzer Timothy (Chief Operating Officer) Sale 56,537 .78 44,098
2025-02-05 Shukla Sath (CEO & President) Sale 155,333 .78 121,159
2025-02-05 Mahadevia Ankit Sale 69,219 .78 53,990
2024-11-08 Rajavelu Esther (CFO & CBO) Sale 17,245 1.30 22,418
2024-11-07 Rajavelu Esther (CFO & CBO) Sale 23,351 1.31 30,589
2024-08-27 Keutzer Timothy (Chief Operating Officer) Sale 2,213 1.35 2,987
2024-08-27 Shukla Sath (CEO & President) Sale 2,757 1.35 3,721
2024-08-27 Mahadevia Ankit Sale 5,912 1.35 7,981
2024-08-05 Shukla Sath (CEO and President) Sale 17,641 1.31 23,109
2024-08-02 Shukla Sath (CEO and President) Sale 14,800 1.32 19,536
2024-02-05 Shukla Sath (CEO and President) Sale 45,093 1.45 65,384
2024-02-02 Hamed Kamal (Chief Medical Officer) Sale 28,075 1.37 38,462
2024-02-02 Keutzer Timothy (Chief Operating Officer) Sale 30,971 1.36 42,120
2024-02-02 Shukla Sath (CEO and President) Sale 30,901 1.37 42,334
2024-02-02 Mahadevia Ankit Sale 63,795 1.37 87,399
2024-02-02 Joseph Tamara L (Chief Legal Officer) Sale 30,906 1.37 42,341
2023-09-13 Hamed Kamal (Chief Medical Officer) Sale 39,496 1.27 50,159
2023-08-29 Shukla Sath (CEO and President) Sale 4,163 1.30 5,411
2023-08-28 Keutzer Timothy (Chief Development Officer) Sale 1,854 1.26 2,336
2023-08-28 Shukla Sath (CEO and President) Sale 1,854 1.26 2,336
2023-08-28 Mahadevia Ankit Sale 9,040 1.26 11,390
2023-08-28 Joseph Tamara L (Chief Legal Officer) Sale 1,854 1.26 2,336
2023-02-03 Mahadevia Ankit (CEO and President) Sale 12,286 1.81 22,237
2023-02-02 Keutzer Timothy (Chief Operating Officer) Sale 3,394 1.86 6,312
2023-02-02 Shukla Sath (Chief Financial Officer) Sale 9,504 1.83 17,373
2023-02-02 Joseph Tamara L (Chief Legal Officer) Sale 3,394 1.86 6,312
2022-09-22 Aquilo Capital, L.p. (10% Owner) Sale 1,901,796 2.25 4,279,041
2022-04-26 Aquilo Capital, L.p. (10% Owner) Buy 39,727 5.24 207,970
2022-03-30 Aquilo Capital, L.p. (10% Owner) Buy 50,000 8.79 439,400
2022-03-14 Aquilo Capital, L.p. (10% Owner) Buy 23,708 7.63 180,797
2022-02-28 Aquilo Capital, L.p. (10% Owner) Buy 44,833 9.53 427,213
2022-02-18 Aquilo Capital, L.p. (10% Owner) Buy 14,828 9.24 137,040
2022-01-31 Aquilo Capital, L.p. (10% Owner) Buy 125,000 11.59 1,448,250
2022-01-24 Aquilo Capital, L.p. (10% Owner) Buy 1,599 10.89 17,417
2022-01-18 Aquilo Capital, L.p. (10% Owner) Buy 48,488 12.41 601,978
2022-01-10 Aquilo Capital, L.p. (10% Owner) Buy 8,867 12.93 114,605
2021-12-31 Aquilo Capital, L.p. (10% Owner) Buy 125,000 15.75 1,969,000
2021-12-30 Aquilo Capital, L.p. (10% Owner) Buy 50,000 15.77 788,600
2021-12-29 Aquilo Capital, L.p. (10% Owner) Buy 75,493 14.64 1,105,293
2021-12-27 Mahadevia Ankit (CEO and President) Sale 8,000 14.58 116,664
2021-12-27 Mahadevia Ankit (CEO and President) Option Ex 8,000 5.90 47,200
2021-10-29 Aquilo Capital, L.p. (10% Owner) Buy 150,000 17.54 2,630,250
2021-09-30 Aquilo Capital, L.p. (10% Owner) Buy 134,543 18.65 2,509,226
2021-09-14 Aquilo Capital, L.p. (10% Owner) Buy 2,156 18.49 39,873
2021-09-13 Aquilo Capital, L.p. (10% Owner) Buy 44,210 18.56 820,670
2021-09-09 Aquilo Capital, L.p. (10% Owner) Buy 24,749 18.50 457,782
2021-08-31 Aquilo Capital, L.p. (10% Owner) Buy 48,645 18.93 920,655
2021-08-30 Aquilo Capital, L.p. (10% Owner) Buy 44,042 17.87 786,854
2021-08-24 Aquilo Capital, L.p. (10% Owner) Buy 40,170 16.28 653,806
2021-08-23 Aquilo Capital, L.p. (10% Owner) Buy 137,835 16.33 2,251,396
2021-08-20 Aquilo Capital, L.p. (10% Owner) Buy 221,190 14.86 3,286,883
2021-02-08 Aquilo Capital, L.p. (10% Owner) Sale 3,000 21.74 65,214
2021-02-04 Aquilo Capital, L.p. (10% Owner) Sale 34,144 18.99 648,257
2021-02-03 Aquilo Capital, L.p. (10% Owner) Sale 29,354 18.98 557,109
2021-02-02 Aquilo Capital, L.p. (10% Owner) Sale 22,841 18.99 433,773
2021-02-01 Aquilo Capital, L.p. (10% Owner) Sale 13,661 19.24 262,864
2020-12-17 Aquilo Capital, L.p. (10% Owner) Sale 250,000 18.81 4,703,250
2020-12-16 Larkin Cristina (Chief Operating Officer) Sale 12,000 19.00 228,000
2020-12-16 Larkin Cristina (Chief Operating Officer) Option Ex 12,000 5.90 70,800
2020-12-16 Aquilo Capital, L.p. (10% Owner) Sale 14,933 18.62 278,037
2020-11-09 Aquilo Capital, L.p. (10% Owner) Sale 125,900 13.77 1,734,020
2020-11-06 Aquilo Capital, L.p. (10% Owner) Sale 5,000 13.78 68,875
2020-11-05 Aquilo Capital, L.p. (10% Owner) Sale 96,600 13.98 1,350,371
2020-11-04 Mahadevia Ankit (CEO and President) Sale 7,370 14.43 106,334
2020-11-04 Mahadevia Ankit (CEO and President) Option Ex 7,370 5.90 43,483
2020-11-04 Aquilo Capital, L.p. (10% Owner) Sale 72,500 14.26 1,033,777
2020-11-03 Mahadevia Ankit (CEO and President) Sale 2,137 14.27 30,490
2020-11-03 Mahadevia Ankit (CEO and President) Option Ex 2,137 5.90 12,608
2020-10-23 Mahadevia Ankit (CEO and President) Sale 20 14.25 285
2020-10-23 Mahadevia Ankit (CEO and President) Option Ex 20 5.90 118
2020-10-14 Mahadevia Ankit (CEO and President) Sale 105 14.25 1,496
2020-10-14 Mahadevia Ankit (CEO and President) Option Ex 105 5.90 619
2020-10-13 Mahadevia Ankit (CEO and President) Sale 14,367 14.28 205,218
2020-10-13 Mahadevia Ankit (CEO and President) Option Ex 14,367 5.90 84,765
2020-09-08 Mahadevia Ankit (CEO and President) Sale 774 14.25 11,029
2020-09-08 Mahadevia Ankit (CEO and President) Option Ex 774 5.90 4,566
2020-07-09 Mahadevia Ankit (CEO and President) Sale 2,293 14.31 32,805
2020-07-09 Mahadevia Ankit (CEO and President) Option Ex 2,293 5.90 13,528
2020-07-07 Mahadevia Ankit (CEO and President) Sale 754 14.25 10,745
2020-07-07 Mahadevia Ankit (CEO and President) Option Ex 754 5.90 4,448
2018-07-17 Glaxosmithkline Plc Buy 80,000 12.50 1,000,000
2018-07-06 Mahadevia Ankit (See Remarks) Sale 1,600 17.68 28,289
2018-07-06 Mahadevia Ankit (See Remarks) Option Ex 1,600 5.90 9,440
2018-07-05 Larkin Cristina (Chief Operating Officer) Sale 4,000 17.50 70,000
2018-07-05 Larkin Cristina (Chief Operating Officer) Option Ex 4,000 5.90 23,600
2018-07-05 Mahadevia Ankit (See Remarks) Sale 3,076 17.62 54,205
2018-07-05 Mahadevia Ankit (See Remarks) Option Ex 3,076 5.90 18,148
2018-07-05 Sendek Joel (Chief Financial Officer) Sale 2,000 17.50 35,000
2018-07-05 Sendek Joel (Chief Financial Officer) Option Ex 2,000 5.90 11,800
2017-11-06 Larkin Cristina (Chief Operating Officer) Buy 1,500 14.00 21,000
2017-11-06 Goyal Vikas (Director) Buy 428,571 14.00 5,999,994
2017-11-06 Sendek Joel (Chief Financial Officer) Buy 5,000 14.00 70,000
2017-11-06 Breum Casper (Director) Buy 214,285 14.00 2,999,990
2017-11-06 Glaxosmithkline Plc Buy 428,571 14.00 5,999,994
2017-11-06 Formela Jean Francois (Director) Buy 428,571 14.00 5,999,994

Insider trading activities including stock purchases, stock sales, and option exercises of SPRO listed in the above tables cannot be completely guaranteed as to their accuracy. For more insider trading information of Spero Therapeutics, Inc. (symbol SPRO, CIK number 1701108) see the Securities and Exchange Commission (SEC) website.



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