Insider trading activities (stock purchases, sales, and option exercises) reported by insiders of Spark Therapeutics, Inc. (ONCE) since 2015 are shown in Table 1 and Table 2. Table 1 shows the monthly insider trading data of Spark Therapeutics, Inc.. Table 2 shows the detailed insider transactions. This company's CIK number is 1609351.
Total stock buying since 2015: $7,970,583.
Total stock sales since 2015: $652,432,712.
Total stock option exercises since 2015: $25,906,533.
| Insider Buying | Insider Sales | Option Exercises | ||||
|---|---|---|---|---|---|---|
| Year | Shares | Value | Shares | Value | Shares | Value |
| 2019 | 0 | $0 | 2,000,000 | $226,000,000 | 536,866 | $19,542,365 |
| 2018 | 0 | $0 | 40,000 | $3,200,529 | 76,125 | $2,010,299 |
| 2017 | 47 | $3,953 | 2,547,763 | $180,886,502 | 370,250 | $3,251,651 |
| 2016 | 0 | $0 | 2,748,480 | $144,340,404 | 148,000 | $534,221 |
| 2015 | 340,700 | $7,966,630 | 2,109,615 | $98,005,277 | 97,333 | $567,997 |
| Trading Period | Insider Buying | Insider Sales | Option Exercises | |||
|---|---|---|---|---|---|---|
| year-month | Shares | Value | Shares | Value | Shares | Value |
| 2019-06 | 0 | $0 | 0 | $0 | 8,375 | $0 |
| 2019-05 | 0 | $0 | 0 | $0 | 10,500 | $0 |
| 2019-03 | 0 | $0 | 0 | $0 | 448,376 | $19,414,015 |
| 2019-02 | 0 | $0 | 2,000,000 | $226,000,000 | 0 | $0 |
| 2019-01 | 0 | $0 | 0 | $0 | 69,615 | $128,350 |
| 2018-12 | 0 | $0 | 0 | $0 | 6,000 | $20,700 |
| 2018-06 | 0 | $0 | 0 | $0 | 8,375 | $0 |
| 2018-05 | 0 | $0 | 0 | $0 | 9,000 | $0 |
| 2018-04 | 0 | $0 | 40,000 | $3,200,529 | 40,000 | $1,989,599 |
| 2018-01 | 0 | $0 | 0 | $0 | 12,750 | $0 |
| 2017-12 | 18 | $1,322 | 18 | $833 | 60,000 | $207,000 |
| 2017-11 | 0 | $0 | 40,529 | $2,886,109 | 40,500 | $139,724 |
| 2017-10 | 29 | $2,631 | 12,500 | $1,023,700 | 12,500 | $299,398 |
| 2017-09 | 0 | $0 | 1,021,000 | $86,383,345 | 47,250 | $1,470,994 |
| 2017-08 | 0 | $0 | 85,000 | $6,726,849 | 85,000 | $293,249 |
| 2017-07 | 0 | $0 | 235,864 | $16,887,939 | 24,006 | $185,329 |
| 2017-06 | 0 | $0 | 52,796 | $3,242,720 | 46,494 | $314,168 |
| 2017-05 | 0 | $0 | 844,500 | $47,522,850 | 4,500 | $169,290 |
| 2017-04 | 0 | $0 | 45,000 | $2,522,445 | 45,000 | $155,249 |
| 2017-03 | 0 | $0 | 37,745 | $2,450,926 | 5,000 | $17,250 |
| 2017-02 | 0 | $0 | 172,811 | $11,238,786 | 0 | $0 |
| 2016-12 | 0 | $0 | 475,188 | $25,725,181 | 3,000 | $10,350 |
| 2016-11 | 0 | $0 | 10,000 | $603,000 | 0 | $0 |
| 2016-10 | 0 | $0 | 8,000 | $455,615 | 8,000 | $27,600 |
| Trade Date | Insider Name | Trade Type | Shares | Price ($) | Value ($) |
|---|---|---|---|---|---|
| 2019-06-26 | Mingozzi Federico (Chief Scientific Officer) | Option Ex | 8,375 | .00 | 0 |
| 2019-05-30 | Mehra Anand | Option Ex | 1,500 | .00 | 0 |
| 2019-05-30 | Altschuler Steven | Option Ex | 1,500 | .00 | 0 |
| 2019-05-30 | Ekman Lars | Option Ex | 1,500 | .00 | 0 |
| 2019-05-30 | Zoth Lota S. | Option Ex | 1,500 | .00 | 0 |
| 2019-05-30 | Perez Robert J | Option Ex | 1,500 | .00 | 0 |
| 2019-05-30 | Sigal Elliot | Option Ex | 1,500 | .00 | 0 |
| 2019-05-30 | Milano Vincent | Option Ex | 1,500 | .00 | 0 |
| 2019-03-25 | Faga Daniel (Chief Business Officer) | Option Ex | 102,750 | 48.11 | 4,943,610 |
| 2019-03-25 | La Barge Joseph (Chief Legal Officer) | Option Ex | 95,003 | 53.90 | 5,120,946 |
| 2019-03-21 | High Katherine A (See Remarks) | Option Ex | 188,124 | 46.85 | 8,813,609 |
| 2019-03-19 | La Barge Joseph (Chief Legal Officer) | Option Ex | 12,559 | 28.95 | 363,557 |
| 2019-03-15 | Marrazzo Jeffrey D (Chief Executive Officer) | Option Ex | 49,940 | 3.45 | 172,293 |
| 2019-02-27 | Children's Hospital Of Philadelphia Foundation (10% Owner) | Sale | 2,000,000 | 113.00 | 226,000,000 |
| 2019-01-18 | Dalton Lisa (Chief Human Resource Officer) | Option Ex | 4,162 | .00 | 0 |
| 2019-01-18 | Mingozzi Federico (Chief Scientific Officer) | Option Ex | 2,000 | .00 | 0 |
| 2019-01-18 | Faga Daniel (Chief Business Officer) | Option Ex | 4,500 | .00 | 0 |
| 2019-01-18 | La Barge Joseph (Chief Legal Officer) | Option Ex | 3,750 | .00 | 0 |
| 2019-01-18 | Marrazzo Jeffrey D (Chief Executive Officer) | Option Ex | 8,750 | .00 | 0 |
| 2019-01-18 | High Katherine A (See Remarks) | Option Ex | 4,500 | .00 | 0 |
| 2019-01-18 | Webster Stephen W (Chief Financial Officer) | Option Ex | 3,750 | .00 | 0 |
| 2019-01-04 | Mehra Anand | Option Ex | 37,203 | 3.45 | 128,350 |
| 2019-01-03 | Perez Robert J | Option Ex | 1,000 | .00 | 0 |
| 2018-12-28 | Marrazzo Jeffrey D (Chief Executive Officer) | Option Ex | 6,000 | 3.45 | 20,700 |
| 2018-06-26 | Mingozzi Federico (Chief Scientific Officer) | Option Ex | 8,375 | .00 | 0 |
| 2018-05-31 | Mehra Anand | Option Ex | 1,500 | .00 | 0 |
| 2018-05-31 | Altschuler Steven | Option Ex | 1,500 | .00 | 0 |
| 2018-05-31 | Ekman Lars | Option Ex | 1,500 | .00 | 0 |
| 2018-05-31 | Zoth Lota S. | Option Ex | 1,500 | .00 | 0 |
| 2018-05-31 | Sigal Elliot | Option Ex | 1,500 | .00 | 0 |
| 2018-05-31 | Milano Vincent | Option Ex | 1,500 | .00 | 0 |
| 2018-04-20 | Furey John (Chief Operating Officer) | Sale | 6,723 | 82.50 | 554,647 |
| 2018-04-20 | Furey John (Chief Operating Officer) | Option Ex | 6,723 | 49.74 | 334,402 |
| 2018-04-18 | Furey John (Chief Operating Officer) | Sale | 11,000 | 82.53 | 907,830 |
| 2018-04-18 | Furey John (Chief Operating Officer) | Option Ex | 11,000 | 49.74 | 547,140 |
| 2018-04-17 | Furey John (Chief Operating Officer) | Sale | 2,277 | 82.50 | 187,852 |
| 2018-04-17 | Furey John (Chief Operating Officer) | Option Ex | 2,277 | 49.74 | 113,257 |
| 2018-04-12 | Furey John (Chief Operating Officer) | Sale | 20,000 | 77.51 | 1,550,200 |
| 2018-04-12 | Furey John (Chief Operating Officer) | Option Ex | 20,000 | 49.74 | 994,800 |
| 2018-01-18 | Faga Daniel (Chief Business Officer) | Option Ex | 2,000 | .00 | 0 |
| 2018-01-18 | La Barge Joseph (Chief Legal Officer) | Option Ex | 1,750 | .00 | 0 |
| 2018-01-18 | Marrazzo Jeffrey D (Chief Executive Officer) | Option Ex | 5,000 | .00 | 0 |
| 2018-01-18 | High Katherine A (See Remarks) | Option Ex | 2,250 | .00 | 0 |
| 2018-01-18 | Webster Stephen W (Chief Financial Officer) | Option Ex | 1,750 | .00 | 0 |
| 2017-12-19 | Marrazzo Jeffrey D (Chief Executive Officer) | Option Ex | 60,000 | 3.45 | 207,000 |
| 2017-12-11 | Furey John (Chief Operating Officer) | Sale | 18 | 46.33 | 833 |
| 2017-12-08 | Furey John (Chief Operating Officer) | Buy | 18 | 73.48 | 1,322 |
| 2017-11-28 | High Katherine A (See Remarks) | Sale | 5,000 | 71.59 | 357,950 |
| 2017-11-28 | High Katherine A (See Remarks) | Option Ex | 5,000 | 3.45 | 17,250 |
| 2017-11-28 | Sigal Elliot | Sale | 29 | 72.43 | 2,100 |
| 2017-11-16 | Webster Stephen W (Chief Financial Officer) | Sale | 10,000 | 70.14 | 701,400 |
| 2017-11-16 | Webster Stephen W (Chief Financial Officer) | Option Ex | 10,000 | 3.45 | 34,500 |
| 2017-11-13 | La Barge Joseph (Chief Legal Officer) | Sale | 2,191 | 71.65 | 156,985 |
| 2017-11-13 | La Barge Joseph (Chief Legal Officer) | Option Ex | 2,191 | 3.45 | 7,558 |
| 2017-11-13 | Marrazzo Jeffrey D (Chief Executive Officer) | Sale | 20,000 | 71.54 | 1,430,800 |
| 2017-11-13 | Marrazzo Jeffrey D (Chief Executive Officer) | Option Ex | 20,000 | 3.45 | 69,000 |
| 2017-11-09 | La Barge Joseph (Chief Legal Officer) | Sale | 3,309 | 71.58 | 236,874 |
| 2017-11-09 | La Barge Joseph (Chief Legal Officer) | Option Ex | 3,309 | 3.45 | 11,416 |
| 2017-10-31 | High Katherine A (See Remarks) | Sale | 5,000 | 83.30 | 416,500 |
| 2017-10-31 | High Katherine A (See Remarks) | Option Ex | 5,000 | 3.45 | 17,250 |
| 2017-10-24 | Faga Daniel (Chief Business Officer) | Sale | 1,500 | 85.00 | 127,500 |
| 2017-10-24 | Faga Daniel (Chief Business Officer) | Option Ex | 1,500 | 37.62 | 56,429 |
| 2017-10-20 | Faga Daniel (Chief Business Officer) | Sale | 6,000 | 79.95 | 479,700 |
| 2017-10-20 | Faga Daniel (Chief Business Officer) | Option Ex | 6,000 | 37.62 | 225,719 |
| 2017-10-12 | Sigal Elliot | Buy | 29 | 90.75 | 2,631 |
| 2017-09-27 | Children's Hospital Of Philadelphia Foundation (10% Owner) | Option Ex | 26,250 | 39.61 | 1,039,762 |
| 2017-09-26 | High Katherine A (See Remarks) | Sale | 5,000 | 85.81 | 429,050 |
| 2017-09-26 | High Katherine A (See Remarks) | Option Ex | 5,000 | 3.45 | 17,250 |
| 2017-09-21 | Children's Hospital Of Philadelphia Foundation (Director) | Sale | 1,000,000 | 84.63 | 84,630,000 |
| 2017-09-19 | Faga Daniel (Chief Business Officer) | Sale | 1,500 | 85.00 | 127,500 |
| 2017-09-19 | Faga Daniel (Chief Business Officer) | Option Ex | 1,500 | 37.62 | 56,429 |
| 2017-09-12 | Faga Daniel (Chief Business Officer) | Sale | 6,000 | 82.86 | 497,130 |
| 2017-09-12 | Faga Daniel (Chief Business Officer) | Option Ex | 6,000 | 37.62 | 225,719 |
| 2017-09-07 | Faga Daniel (Chief Business Officer) | Sale | 3,000 | 85.02 | 255,045 |
| 2017-09-07 | Faga Daniel (Chief Business Officer) | Option Ex | 3,000 | 37.62 | 112,859 |
| 2017-09-05 | La Barge Joseph (Chief Legal Officer) | Sale | 5,500 | 80.84 | 444,620 |
| 2017-09-05 | La Barge Joseph (Chief Legal Officer) | Option Ex | 5,500 | 3.45 | 18,975 |
| 2017-08-29 | High Katherine A (See Remarks) | Sale | 10,000 | 80.61 | 806,050 |
| 2017-08-29 | High Katherine A (See Remarks) | Option Ex | 10,000 | 3.45 | 34,500 |
| 2017-08-23 | Marrazzo Jeffrey D (Chief Executive Officer) | Sale | 21,350 | 80.01 | 1,708,213 |
| 2017-08-23 | Marrazzo Jeffrey D (Chief Executive Officer) | Option Ex | 21,350 | 3.45 | 73,657 |
| 2017-08-15 | Webster Stephen W (Chief Financial Officer) | Sale | 10,000 | 79.38 | 793,800 |
| 2017-08-15 | Webster Stephen W (Chief Financial Officer) | Option Ex | 10,000 | 3.45 | 34,500 |
| 2017-08-11 | Marrazzo Jeffrey D (Chief Executive Officer) | Sale | 15,000 | 75.10 | 1,126,500 |
| 2017-08-11 | Marrazzo Jeffrey D (Chief Executive Officer) | Option Ex | 15,000 | 3.45 | 51,750 |
| 2017-08-02 | Marrazzo Jeffrey D (Chief Executive Officer) | Sale | 28,650 | 80.01 | 2,292,286 |
| 2017-08-02 | Marrazzo Jeffrey D (Chief Executive Officer) | Option Ex | 28,650 | 3.45 | 98,842 |
| 2017-07-31 | Webster Stephen W (Chief Financial Officer) | Sale | 2,337 | 71.12 | 166,207 |
| 2017-07-31 | Webster Stephen W (Chief Financial Officer) | Option Ex | 2,337 | 3.45 | 8,062 |
| 2017-07-25 | High Katherine A (See Remarks) | Sale | 10,000 | 73.18 | 731,800 |
| 2017-07-25 | High Katherine A (See Remarks) | Option Ex | 10,000 | 3.45 | 34,500 |
| 2017-07-24 | Faga Daniel (Chief Business Officer) | Sale | 3,000 | 70.00 | 210,000 |
| 2017-07-24 | Faga Daniel (Chief Business Officer) | Option Ex | 3,000 | 37.62 | 112,859 |
| 2017-07-24 | La Barge Joseph (Chief Legal Officer) | Sale | 3,000 | 70.00 | 210,000 |
| 2017-07-24 | La Barge Joseph (Chief Legal Officer) | Option Ex | 3,000 | 3.45 | 10,350 |
| 2017-07-24 | Mehra Anand | Sale | 211,858 | 71.75 | 15,201,447 |
| 2017-07-05 | Marrazzo Jeffrey D (Chief Executive Officer) | Sale | 5,669 | 65.00 | 368,485 |
| 2017-07-05 | Marrazzo Jeffrey D (Chief Executive Officer) | Option Ex | 5,669 | 3.45 | 19,558 |
| 2017-06-29 | Faga Daniel (Chief Business Officer) | Sale | 4,500 | 62.71 | 282,195 |
| 2017-06-29 | Faga Daniel (Chief Business Officer) | Option Ex | 4,500 | 37.62 | 169,290 |
| 2017-06-27 | High Katherine A (See Remarks) | Sale | 10,000 | 60.96 | 609,600 |
| 2017-06-27 | High Katherine A (See Remarks) | Option Ex | 10,000 | 3.45 | 34,500 |
| 2017-06-21 | Marrazzo Jeffrey D (Chief Executive Officer) | Sale | 8,797 | 65.00 | 571,805 |
| 2017-06-21 | Marrazzo Jeffrey D (Chief Executive Officer) | Option Ex | 8,797 | 3.45 | 30,349 |
| 2017-06-21 | Mehra Anand | Sale | 5,282 | 65.00 | 343,330 |
| 2017-06-20 | Marrazzo Jeffrey D (Chief Executive Officer) | Sale | 534 | 65.00 | 34,710 |
| 2017-06-20 | Marrazzo Jeffrey D (Chief Executive Officer) | Option Ex | 534 | 3.45 | 1,842 |
| 2017-06-20 | Mehra Anand | Sale | 1,020 | 65.00 | 66,300 |
| 2017-06-19 | High Katherine A (See Remarks) | Sale | 10,000 | 60.00 | 600,000 |
| 2017-06-19 | High Katherine A (See Remarks) | Option Ex | 10,000 | 3.45 | 34,500 |
| 2017-06-19 | Webster Stephen W (Chief Financial Officer) | Sale | 7,663 | 60.00 | 459,780 |
| 2017-06-19 | Webster Stephen W (Chief Financial Officer) | Option Ex | 7,663 | 3.45 | 26,437 |
| 2017-06-07 | La Barge Joseph (General Counsel) | Sale | 5,000 | 55.00 | 275,000 |
| 2017-06-07 | La Barge Joseph (General Counsel) | Option Ex | 5,000 | 3.45 | 17,250 |
| 2017-05-15 | Faga Daniel (Chief Business Officer) | Sale | 4,500 | 56.90 | 256,050 |
| 2017-05-15 | Faga Daniel (Chief Business Officer) | Option Ex | 4,500 | 37.62 | 169,290 |
| 2017-05-11 | Children's Hospital Of Philadelphia Foundation (Director) | Sale | 840,000 | 56.27 | 47,266,800 |
| 2017-04-28 | High Katherine A (See Remarks) | Sale | 15,000 | 58.06 | 870,900 |
| 2017-04-28 | High Katherine A (See Remarks) | Option Ex | 15,000 | 3.45 | 51,750 |
| 2017-04-25 | High Katherine A (See Remarks) | Sale | 12,940 | 55.70 | 720,693 |
| 2017-04-25 | High Katherine A (See Remarks) | Option Ex | 12,940 | 3.45 | 44,643 |
| 2017-04-25 | Webster Stephen W (Chief Financial Officer) | Sale | 8,102 | 55.22 | 447,392 |
| 2017-04-25 | Webster Stephen W (Chief Financial Officer) | Option Ex | 8,102 | 3.45 | 27,951 |
| 2017-04-24 | High Katherine A (See Remarks) | Sale | 2,060 | 55.01 | 113,320 |
| 2017-04-24 | High Katherine A (See Remarks) | Option Ex | 2,060 | 3.45 | 7,107 |
| 2017-04-24 | Webster Stephen W (Chief Financial Officer) | Sale | 1,898 | 55.00 | 104,390 |
| 2017-04-24 | Webster Stephen W (Chief Financial Officer) | Option Ex | 1,898 | 3.45 | 6,548 |
| 2017-04-03 | La Barge Joseph (General Counsel) | Sale | 5,000 | 53.15 | 265,750 |
| 2017-04-03 | La Barge Joseph (General Counsel) | Option Ex | 5,000 | 3.45 | 17,250 |
| 2017-03-02 | Mehra Anand | Sale | 15,275 | 65.01 | 993,027 |
| 2017-03-01 | La Barge Joseph (General Counsel) | Sale | 5,000 | 64.44 | 322,175 |
| 2017-03-01 | La Barge Joseph (General Counsel) | Option Ex | 5,000 | 3.45 | 17,250 |
| 2017-03-01 | Mehra Anand | Sale | 17,470 | 65.01 | 1,135,724 |
| 2017-02-28 | Mehra Anand | Sale | 25,274 | 65.02 | 1,643,315 |
| 2017-02-27 | Mehra Anand | Sale | 41,910 | 65.02 | 2,724,988 |
| 2017-02-17 | Mehra Anand | Sale | 7,535 | 65.01 | 489,850 |
| 2017-02-16 | Mehra Anand | Sale | 2,900 | 65.01 | 188,529 |
| 2017-02-15 | Mehra Anand | Sale | 31,497 | 65.03 | 2,048,249 |
| 2017-02-14 | Mehra Anand | Sale | 950 | 65.02 | 61,768 |
| 2017-02-09 | Mehra Anand | Sale | 37,411 | 65.06 | 2,433,959 |
| 2017-02-07 | Mehra Anand | Sale | 1,994 | 65.04 | 129,689 |
| 2017-02-06 | Mehra Anand | Sale | 1,010 | 65.00 | 65,650 |
| 2017-02-03 | Mehra Anand | Sale | 22,330 | 65.06 | 1,452,789 |
| 2016-12-16 | Mehra Anand | Sale | 279,728 | 54.09 | 15,129,088 |
| 2016-12-15 | La Barge Joseph (See remarks) | Sale | 3,000 | 53.31 | 159,930 |
| 2016-12-15 | La Barge Joseph (See remarks) | Option Ex | 3,000 | 3.45 | 10,350 |
| 2016-12-15 | Mehra Anand | Sale | 69,928 | 53.07 | 3,711,078 |
| 2016-12-13 | Mehra Anand | Sale | 22,281 | 53.32 | 1,188,022 |
| 2016-12-09 | Mehra Anand | Sale | 100,251 | 55.23 | 5,537,063 |
| 2016-11-14 | High Katherine A (See Remarks) | Sale | 10,000 | 60.30 | 603,000 |
| 2016-10-17 | Marrazzo Jeffrey D (Chief Executive Officer) | Sale | 5,000 | 54.97 | 274,865 |
| 2016-10-17 | Marrazzo Jeffrey D (Chief Executive Officer) | Option Ex | 5,000 | 3.45 | 17,250 |
| 2016-10-03 | La Barge Joseph (See remarks) | Sale | 3,000 | 60.25 | 180,750 |
| 2016-10-03 | La Barge Joseph (See remarks) | Option Ex | 3,000 | 3.45 | 10,350 |
| 2016-09-16 | Marrazzo Jeffrey D (Chief Executive Officer) | Sale | 10,000 | 62.59 | 625,930 |
| 2016-09-16 | Marrazzo Jeffrey D (Chief Executive Officer) | Option Ex | 10,000 | 3.45 | 34,500 |
| 2016-09-15 | High Katherine A (See Remarks) | Sale | 10,000 | 60.77 | 607,650 |
| 2016-08-16 | Children's Hospital Of Philadelphia Foundation (Director) | Sale | 1,000,000 | 60.90 | 60,900,000 |
| 2016-08-15 | Marrazzo Jeffrey D (Chief Executive Officer) | Sale | 10,000 | 63.32 | 633,200 |
| 2016-08-15 | Marrazzo Jeffrey D (Chief Executive Officer) | Option Ex | 10,000 | 3.45 | 34,500 |
| 2016-08-15 | High Katherine A (See Remarks) | Sale | 10,000 | 63.30 | 633,000 |
| 2016-08-11 | Marrazzo Jeffrey D (Chief Executive Officer) | Sale | 9,999 | 60.06 | 600,539 |
| 2016-08-11 | Marrazzo Jeffrey D (Chief Executive Officer) | Option Ex | 9,999 | 3.45 | 34,496 |
| 2016-08-11 | Mehra Anand | Sale | 23,063 | 60.81 | 1,402,461 |
| 2016-08-10 | Marrazzo Jeffrey D (Chief Executive Officer) | Sale | 6,971 | 60.02 | 418,399 |
| 2016-08-10 | Marrazzo Jeffrey D (Chief Executive Officer) | Option Ex | 6,971 | 3.45 | 24,049 |
| 2016-08-10 | High Katherine A (See Remarks) | Sale | 1,890 | 60.00 | 113,400 |
| 2016-08-10 | Mehra Anand | Sale | 6,900 | 60.02 | 414,138 |
| 2016-08-08 | Marrazzo Jeffrey D (Chief Executive Officer) | Sale | 800 | 60.27 | 48,216 |
| 2016-08-08 | Marrazzo Jeffrey D (Chief Executive Officer) | Option Ex | 800 | 3.45 | 2,760 |
| 2016-08-08 | High Katherine A (See Remarks) | Sale | 400 | 60.30 | 24,120 |
| 2016-08-08 | Mehra Anand | Sale | 100 | 60.47 | 6,047 |
| 2016-08-04 | Marrazzo Jeffrey D (Chief Executive Officer) | Sale | 100 | 60.00 | 6,000 |
| 2016-08-04 | Marrazzo Jeffrey D (Chief Executive Officer) | Option Ex | 100 | 3.45 | 345 |
| 2016-08-04 | High Katherine A (See Remarks) | Sale | 100 | 60.00 | 6,000 |
| 2016-08-04 | Mehra Anand | Sale | 452 | 60.00 | 27,120 |
| 2016-08-03 | Marrazzo Jeffrey D (Chief Executive Officer) | Sale | 4,182 | 60.00 | 250,920 |
| 2016-08-03 | Marrazzo Jeffrey D (Chief Executive Officer) | Option Ex | 4,182 | 3.45 | 14,427 |
| 2016-08-03 | High Katherine A (See Remarks) | Sale | 3,627 | 60.00 | 217,620 |
| 2016-08-03 | Mehra Anand | Sale | 4,612 | 60.00 | 276,720 |
| 2016-08-01 | Marrazzo Jeffrey D (Chief Executive Officer) | Sale | 12,348 | 60.03 | 741,250 |
| 2016-08-01 | Marrazzo Jeffrey D (Chief Executive Officer) | Option Ex | 12,348 | 3.45 | 42,600 |
| 2016-08-01 | High Katherine A (See Remarks) | Sale | 13,983 | 60.02 | 839,259 |
| 2016-08-01 | Mehra Anand | Sale | 22,665 | 60.03 | 1,360,579 |
| 2016-07-18 | Marrazzo Jeffrey D (Chief Executive Officer) | Sale | 5,000 | 52.53 | 262,650 |
| 2016-07-18 | Marrazzo Jeffrey D (Chief Executive Officer) | Option Ex | 5,000 | 3.45 | 17,250 |
| 2016-07-15 | Vivaldi Coelho Rogerio (Chief Commercial Officer) | Sale | 7,000 | 53.14 | 371,980 |
| 2016-07-15 | Vivaldi Coelho Rogerio (Chief Commercial Officer) | Option Ex | 7,000 | 4.80 | 33,600 |
| 2016-07-05 | La Barge Joseph (See remarks) | Sale | 3,000 | 52.36 | 157,080 |
| 2016-07-05 | La Barge Joseph (See remarks) | Option Ex | 3,000 | 3.45 | 10,350 |
| 2016-06-20 | Children's Hospital Of Philadelphia Foundation (10% Owner) | Sale | 1,000,000 | 42.30 | 42,300,000 |
| 2016-06-15 | Marrazzo Jeffrey D (Chief Executive Officer) | Sale | 5,000 | 47.26 | 236,290 |
| 2016-06-15 | Marrazzo Jeffrey D (Chief Executive Officer) | Option Ex | 5,000 | 3.45 | 17,250 |
| 2016-05-31 | Marrazzo Jeffrey D (Chief Executive Officer) | Sale | 600 | 60.00 | 36,000 |
| 2016-05-31 | Marrazzo Jeffrey D (Chief Executive Officer) | Option Ex | 600 | 3.45 | 2,070 |
| 2016-05-31 | Mehra Anand | Sale | 500 | 60.00 | 30,000 |
| 2016-05-24 | High Katherine A (See Remarks) | Sale | 10,000 | 54.00 | 540,000 |
| 2016-05-23 | High Katherine A (See Remarks) | Sale | 10,000 | 54.66 | 546,650 |
| 2016-05-20 | La Barge Joseph (See remarks) | Sale | 2,500 | 50.00 | 125,000 |
| 2016-05-20 | La Barge Joseph (See remarks) | Option Ex | 2,500 | 3.45 | 8,625 |
| 2016-05-20 | Webster Stephen W (Chief Financial Officer) | Sale | 20,000 | 50.39 | 1,007,800 |
| 2016-05-20 | Webster Stephen W (Chief Financial Officer) | Option Ex | 20,000 | 3.45 | 69,000 |
| 2016-05-19 | La Barge Joseph (See remarks) | Sale | 7,500 | 46.87 | 351,525 |
| 2016-05-19 | La Barge Joseph (See remarks) | Option Ex | 7,500 | 3.45 | 25,875 |
| 2016-05-19 | Marrazzo Jeffrey D (Chief Executive Officer) | Sale | 25,000 | 46.36 | 1,158,925 |
| 2016-05-19 | Marrazzo Jeffrey D (Chief Executive Officer) | Option Ex | 25,000 | 3.45 | 86,250 |
| 2016-04-21 | Vivaldi Coelho Rogerio (Chief Commercial Officer) | Sale | 1,200 | 40.02 | 48,024 |
| 2016-04-21 | Vivaldi Coelho Rogerio (Chief Commercial Officer) | Option Ex | 1,200 | 5.47 | 6,570 |
| 2016-04-20 | Vivaldi Coelho Rogerio (Chief Commercial Officer) | Sale | 5,800 | 40.02 | 232,116 |
| 2016-04-20 | Vivaldi Coelho Rogerio (Chief Commercial Officer) | Option Ex | 5,800 | 5.47 | 31,754 |
| 2015-12-28 | Children's Hospital Of Philadelphia Foundation (10% Owner) | Sale | 131,505 | 44.18 | 5,809,890 |
| 2015-12-21 | Children's Hospital Of Philadelphia Foundation (10% Owner) | Sale | 1,000,000 | 44.18 | 44,180,000 |
| 2015-12-01 | High Katherine A (See Remarks) | Sale | 10,000 | 55.31 | 553,100 |
| 2015-11-27 | Mehra Anand | Sale | 5,350 | 60.02 | 321,107 |
| 2015-11-25 | Mehra Anand | Sale | 17,611 | 60.01 | 1,056,836 |
| 2015-11-16 | High Katherine A (See Remarks) | Sale | 10,000 | 53.77 | 537,700 |
| 2015-11-12 | Mehra Anand | Sale | 1,074 | 60.00 | 64,440 |
| 2015-11-11 | Mehra Anand | Sale | 97,644 | 60.13 | 5,871,333 |
| 2015-11-10 | Mehra Anand | Sale | 5,932 | 60.01 | 355,979 |
| 2015-11-09 | Mehra Anand | Sale | 25,955 | 60.07 | 1,559,116 |
| 2015-10-14 | High Katherine A (See Remarks) | Sale | 30,000 | 49.52 | 1,485,450 |
| 2015-10-13 | High Katherine A (See Remarks) | Sale | 10,000 | 48.00 | 480,000 |
| 2015-10-13 | Vivaldi Coelho Rogerio (Chief Commercial Officer) | Sale | 24,000 | 48.15 | 1,155,600 |
| 2015-10-13 | Vivaldi Coelho Rogerio (Chief Commercial Officer) | Option Ex | 37,333 | 7.50 | 279,997 |
| 2015-10-12 | Marrazzo Jeffrey D (Chief Executive Officer) | Sale | 75,000 | 49.12 | 3,684,225 |
| 2015-10-09 | Marrazzo Jeffrey D (Chief Executive Officer) | Sale | 24,983 | 47.83 | 1,194,811 |
| 2015-10-08 | Mehra Anand | Sale | 277,632 | 45.34 | 12,588,667 |
| 2015-10-07 | Marrazzo Jeffrey D (Chief Executive Officer) | Sale | 50,017 | 48.58 | 2,429,975 |
| 2015-10-07 | Vivaldi Coelho Rogerio (Chief Commercial Officer) | Sale | 41,000 | 49.60 | 2,033,804 |
| 2015-10-07 | Vivaldi Coelho Rogerio (Chief Commercial Officer) | Option Ex | 40,000 | 5.47 | 219,000 |
| 2015-10-07 | Mehra Anand | Sale | 251,912 | 46.31 | 11,666,044 |
| 2015-10-07 | Altschuler Steven (Director) | Buy | 5,000 | 49.11 | 245,530 |
| 2015-10-07 | Webster Stephen W (Chief Financial Officer) | Sale | 20,000 | 48.86 | 977,200 |
| 2015-10-07 | Webster Stephen W (Chief Financial Officer) | Option Ex | 20,000 | 3.45 | 69,000 |
| 2015-02-04 | Children's Hospital Of Philadelphia Foundation (10% Owner) | Buy | 100,000 | 23.00 | 2,300,000 |
| 2015-02-04 | High Katherine A (See Remarks) | Buy | 700 | 23.00 | 16,100 |
| 2015-02-04 | Vivaldi Coelho Rogerio (Chief Commercial Officer) | Buy | 2,500 | 23.00 | 57,500 |
| 2015-02-04 | Mehra Anand | Buy | 225,000 | 23.00 | 5,175,000 |
| 2015-02-04 | Webster Stephen W (Chief Financial Officer) | Buy | 2,500 | 23.00 | 57,500 |
| 2015-02-04 | Sigal Elliot (Director) | Buy | 5,000 | 23.00 | 115,000 |
Insider trading activities including stock purchases, stock sales, and option exercises of ONCE listed in the above tables cannot be completely guaranteed as to their accuracy. For more insider trading information of Spark Therapeutics, Inc. (symbol ONCE, CIK number 1609351) see the Securities and Exchange Commission (SEC) website.