Insider trading activities (stock purchases, sales, and option exercises) reported by insiders of Lexicon Pharmaceuticals, Inc. (LXRX) since 2005 are shown in Table 1 and Table 2. Table 1 shows the monthly insider trading data of Lexicon Pharmaceuticals, Inc.. Table 2 shows the detailed insider transactions. This company's CIK number is 1062822.
Total stock buying since 2005: $710,138,480.
Total stock sales since 2005: $1,561,990.
Total stock option exercises since 2005: $1,012,622.
| Insider Buying | Insider Sales | Option Exercises | ||||
|---|---|---|---|---|---|---|
| Year | Shares | Value | Shares | Value | Shares | Value |
| 2025 | 0 | $0 | 0 | $0 | 738,177 | $0 |
| 2024 | 0 | $0 | 0 | $0 | 57,657,998 | $0 |
| 2023 | 28,893,050 | $73,567,062 | 0 | $0 | 638,024 | $0 |
| 2022 | 19,121,600 | $47,804,000 | 0 | $0 | 470,054 | $0 |
| 2021 | 0 | $0 | 22,912 | $158,436 | 528,378 | $39,720 |
| 2020 | 21,875,000 | $70,000,000 | 0 | $0 | 358,442 | $0 |
| 2019 | 800,737 | $1,932,636 | 0 | $0 | 147,190 | $0 |
| 2018 | 1,713,234 | $20,277,481 | 10,000 | $129,080 | 94,621 | $101,500 |
| 2017 | 799,673 | $7,888,384 | 0 | $0 | 72,666 | $0 |
| 2016 | 0 | $0 | 7,500 | $100,500 | 62,647 | $46,725 |
| 2015 | 0 | $0 | 0 | $0 | 235,875 | $0 |
| 2014 | 149,719,627 | $150,417,253 | 0 | $0 | 327,250 | $0 |
| 2013 | 0 | $0 | 0 | $0 | 407,450 | $0 |
| 2012 | 6,000,000 | $13,500,000 | 0 | $0 | 100,000 | $0 |
| 2011 | 0 | $0 | 0 | $0 | 78,211 | $88,377 |
| 2010 | 94,270,206 | $108,410,736 | 0 | $0 | 0 | $0 |
| 2009 | 15,474,145 | $23,212,452 | 0 | $0 | 0 | $0 |
| 2008 | 50,864,986 | $192,959,541 | 0 | $0 | 0 | $0 |
| 2007 | 20,000 | $62,750 | 243,300 | $890,847 | 394,000 | $661,300 |
| 2006 | 25,000 | $98,175 | 52,200 | $269,067 | 30,000 | $75,000 |
| 2005 | 2,000 | $8,010 | 3,800 | $14,060 | 0 | $0 |
| Trading Period | Insider Buying | Insider Sales | Option Exercises | |||
|---|---|---|---|---|---|---|
| year-month | Shares | Value | Shares | Value | Shares | Value |
| 2025-05 | 0 | $0 | 0 | $0 | 220,860 | $0 |
| 2025-02 | 0 | $0 | 0 | $0 | 517,317 | $0 |
| 2024-05 | 0 | $0 | 0 | $0 | 57,546,100 | $0 |
| 2024-04 | 0 | $0 | 0 | $0 | 48,192 | $0 |
| 2024-02 | 0 | $0 | 0 | $0 | 63,706 | $0 |
| 2023-11 | 10,000 | $10,100 | 0 | $0 | 0 | $0 |
| 2023-10 | 1,000,000 | $1,103,993 | 0 | $0 | 0 | $0 |
| 2023-09 | 10,000 | $13,799 | 0 | $0 | 0 | $0 |
| 2023-08 | 6,000 | $11,040 | 0 | $0 | 0 | $0 |
| 2023-06 | 27,867,050 | $72,428,130 | 0 | $0 | 0 | $0 |
| 2023-05 | 0 | $0 | 0 | $0 | 74,416 | $0 |
| 2023-02 | 0 | $0 | 0 | $0 | 563,608 | $0 |
| 2022-08 | 19,121,600 | $47,804,000 | 0 | $0 | 0 | $0 |
| 2022-04 | 0 | $0 | 0 | $0 | 32,192 | $0 |
| 2022-02 | 0 | $0 | 0 | $0 | 437,862 | $0 |
| 2021-04 | 0 | $0 | 0 | $0 | 63,828 | $0 |
| 2021-03 | 0 | $0 | 22,912 | $158,436 | 12,000 | $39,720 |
| 2021-02 | 0 | $0 | 0 | $0 | 452,550 | $0 |
| 2020-12 | 21,875,000 | $70,000,000 | 0 | $0 | 0 | $0 |
| 2020-04 | 0 | $0 | 0 | $0 | 27,728 | $0 |
| 2020-02 | 0 | $0 | 0 | $0 | 330,714 | $0 |
| 2019-09 | 726,737 | $1,839,226 | 0 | $0 | 0 | $0 |
| 2019-08 | 74,000 | $93,410 | 0 | $0 | 0 | $0 |
| 2019-02 | 0 | $0 | 0 | $0 | 147,190 | $0 |
| Trade Date | Insider Name | Trade Type | Shares | Price ($) | Value ($) |
|---|---|---|---|---|---|
| 2025-05-13 | Sullivan Diane E. (Director) | Option Ex | 36,810 | .00 | 0 |
| 2025-05-13 | Swain Judith L (Director) | Option Ex | 36,810 | .00 | 0 |
| 2025-05-13 | Amouyal Philippe (Director) | Option Ex | 36,810 | .00 | 0 |
| 2025-05-13 | Barker Sam L (Director) | Option Ex | 36,810 | .00 | 0 |
| 2025-05-13 | Sobecki Christopher J (Director) | Option Ex | 36,810 | .00 | 0 |
| 2025-05-13 | Debbane Raymond (Director) | Option Ex | 36,810 | .00 | 0 |
| 2025-02-28 | Mcdermott Wendy (SVP, Human Resources) | Option Ex | 98,956 | .00 | 0 |
| 2025-02-28 | Granowitz Craig B (SVP, Chief Medical Officer) | Option Ex | 137,934 | .00 | 0 |
| 2025-02-28 | Defrancesco Lisa (SVP, IR and Corp Comm) | Option Ex | 24,673 | .00 | 0 |
| 2025-02-28 | Crum Brian T (SVP, General Counsel & Secr.) | Option Ex | 128,940 | .00 | 0 |
| 2025-02-28 | Main Alan J (EVP, Innov & Chem Sciences) | Option Ex | 126,814 | .00 | 0 |
| 2024-05-10 | Invus Advisors, L.l.c. | Option Ex | 57,546,100 | .00 | 0 |
| 2024-04-28 | Swain Judith L (Director) | Option Ex | 8,032 | .00 | 0 |
| 2024-04-28 | Amouyal Philippe (Director) | Option Ex | 8,032 | .00 | 0 |
| 2024-04-28 | Barker Sam L (Director) | Option Ex | 8,032 | .00 | 0 |
| 2024-04-28 | Lefkowitz Robert J Md (Director) | Option Ex | 8,032 | .00 | 0 |
| 2024-04-28 | Sobecki Christopher J (Director) | Option Ex | 8,032 | .00 | 0 |
| 2024-04-28 | Debbane Raymond (Director) | Option Ex | 8,032 | .00 | 0 |
| 2024-02-28 | Granowitz Craig B (SVP, Chief Medical Officer) | Option Ex | 63,706 | .00 | 0 |
| 2023-11-10 | Coats Lonnel (Chief Executive Officer) | Buy | 10,000 | 1.01 | 10,100 |
| 2023-10-12 | Debbane Raymond (Director) | Buy | 148,820 | 1.03 | 153,879 |
| 2023-10-11 | Debbane Raymond (Director) | Buy | 342,874 | 1.08 | 370,646 |
| 2023-10-10 | Debbane Raymond (Director) | Buy | 508,306 | 1.14 | 579,468 |
| 2023-09-14 | Wade Jeffrey L (President and CFO) | Buy | 10,000 | 1.38 | 13,799 |
| 2023-08-04 | Mcdermott Wendy (VP, Human Resources) | Buy | 6,000 | 1.84 | 11,040 |
| 2023-06-29 | Coats Lonnel (Chief Executive Officer) | Buy | 10,000 | 2.16 | 21,600 |
| 2023-06-26 | Coats Lonnel (Chief Executive Officer) | Buy | 10,000 | 2.18 | 21,790 |
| 2023-06-23 | Mcdermott Wendy (VP, Human Resources) | Buy | 10,000 | 2.43 | 24,300 |
| 2023-06-23 | Coats Lonnel (Chief Executive Officer) | Buy | 10,000 | 2.50 | 24,950 |
| 2023-06-22 | Coats Lonnel (Chief Executive Officer) | Buy | 40,000 | 2.31 | 92,400 |
| 2023-06-20 | Wade Jeffrey L (President and CFO) | Buy | 12,000 | 2.33 | 27,960 |
| 2023-06-05 | Invus Advisors, L.l.c. (Director) | Buy | 27,775,050 | 2.60 | 72,215,130 |
| 2023-05-21 | Swain Judith L (Director) | Option Ex | 9,302 | .00 | 0 |
| 2023-05-21 | Amouyal Philippe (Director) | Option Ex | 9,302 | .00 | 0 |
| 2023-05-21 | Palantoni Frank (Director) | Option Ex | 9,302 | .00 | 0 |
| 2023-05-21 | Nies Alan S (Director) | Option Ex | 9,302 | .00 | 0 |
| 2023-05-21 | Barker Sam L (Director) | Option Ex | 9,302 | .00 | 0 |
| 2023-05-21 | Lefkowitz Robert J Md (Director) | Option Ex | 9,302 | .00 | 0 |
| 2023-05-21 | Sobecki Christopher J (Director) | Option Ex | 9,302 | .00 | 0 |
| 2023-05-21 | Debbane Raymond (Director) | Option Ex | 9,302 | .00 | 0 |
| 2023-02-28 | Mcdermott Wendy (VP, Human Resources) | Option Ex | 18,943 | .00 | 0 |
| 2023-02-28 | Seth Kiernan (VP, Chief Commercial Officer) | Option Ex | 43,082 | .00 | 0 |
| 2023-02-28 | Kassler-taub Kenneth B. (SVP, Regulatory & QA) | Option Ex | 52,886 | .00 | 0 |
| 2023-02-28 | Alexander Kristen (VP, Finance and Accounting) | Option Ex | 18,717 | .00 | 0 |
| 2023-02-28 | Granowitz Craig B (SVP, Chief Medical Officer) | Option Ex | 27,917 | .00 | 0 |
| 2023-02-28 | Crum Brian T (SVP, General Counsel & Secr.) | Option Ex | 55,877 | .00 | 0 |
| 2023-02-28 | Coats Lonnel (Chief Executive Officer) | Option Ex | 209,327 | .00 | 0 |
| 2023-02-28 | Main Alan J (EVP, Innov & Chem Sciences) | Option Ex | 57,943 | .00 | 0 |
| 2023-02-28 | Wade Jeffrey L (President and CFO) | Option Ex | 78,916 | .00 | 0 |
| 2022-08-01 | Invus Advisors, L.l.c. (Director) | Buy | 16,173,800 | 2.50 | 40,434,500 |
| 2022-08-01 | Debbane Raymond (Director) | Buy | 1,965,200 | 2.50 | 4,913,000 |
| 2022-04-30 | Swain Judith L (Director) | Option Ex | 4,024 | .00 | 0 |
| 2022-04-30 | Amouyal Philippe (Director) | Option Ex | 4,024 | .00 | 0 |
| 2022-04-30 | Palantoni Frank (Director) | Option Ex | 4,024 | .00 | 0 |
| 2022-04-30 | Nies Alan S (Director) | Option Ex | 4,024 | .00 | 0 |
| 2022-04-30 | Barker Sam L (Director) | Option Ex | 4,024 | .00 | 0 |
| 2022-04-30 | Lefkowitz Robert J Md (Director) | Option Ex | 4,024 | .00 | 0 |
| 2022-04-30 | Sobecki Christopher J (Director) | Option Ex | 4,024 | .00 | 0 |
| 2022-04-30 | Debbane Raymond (Director) | Option Ex | 4,024 | .00 | 0 |
| 2022-02-28 | Seth Kiernan (VP, Chief Commercial Officer) | Option Ex | 30,128 | .00 | 0 |
| 2022-02-28 | Kassler-taub Kenneth B. (SVP, Regulatory & QA) | Option Ex | 36,628 | .00 | 0 |
| 2022-02-28 | Alexander Kristen (VP, Finance and Accounting) | Option Ex | 11,300 | .00 | 0 |
| 2022-02-28 | Crum Brian T (SVP, General Counsel & Secr.) | Option Ex | 40,880 | .00 | 0 |
| 2022-02-28 | Coats Lonnel (Chief Executive Officer) | Option Ex | 197,343 | .00 | 0 |
| 2022-02-28 | Main Alan J (EVP, Innov & Chem Sciences) | Option Ex | 54,650 | .00 | 0 |
| 2022-02-28 | Wade Jeffrey L (President and CFO) | Option Ex | 66,933 | .00 | 0 |
| 2021-04-24 | Swain Judith L (Director) | Option Ex | 10,638 | .00 | 0 |
| 2021-04-24 | Palantoni Frank (Director) | Option Ex | 10,638 | .00 | 0 |
| 2021-04-24 | Nies Alan S (Director) | Option Ex | 10,638 | .00 | 0 |
| 2021-04-24 | Lefkowitz Robert J Md (Director) | Option Ex | 10,638 | .00 | 0 |
| 2021-04-24 | Sobecki Christopher J (Director) | Option Ex | 10,638 | .00 | 0 |
| 2021-04-24 | Debbane Raymond (Director) | Option Ex | 10,638 | .00 | 0 |
| 2021-03-15 | Tessmer James F (VP, Finance & Accounting) | Sale | 22,912 | 6.92 | 158,436 |
| 2021-03-15 | Tessmer James F (VP, Finance & Accounting) | Option Ex | 12,000 | 3.31 | 39,720 |
| 2021-02-28 | Crum Brian T (VP, General Counsel & Secr.) | Option Ex | 38,765 | .00 | 0 |
| 2021-02-28 | Coats Lonnel (President and CEO) | Option Ex | 192,885 | .00 | 0 |
| 2021-02-28 | Tessmer James F (VP, Finance & Accounting) | Option Ex | 28,316 | .00 | 0 |
| 2021-02-28 | Tyle Praveen (EVP, R&D) | Option Ex | 68,007 | .00 | 0 |
| 2021-02-28 | Main Alan J (EVP, Innov & Chem Sciences) | Option Ex | 56,468 | .00 | 0 |
| 2021-02-28 | Wade Jeffrey L (EVP, Corp Adm Affairs and CFO) | Option Ex | 68,109 | .00 | 0 |
| 2020-12-16 | Stichting Administratiekantoor Westend (Director) | Buy | 10,937,500 | 3.20 | 35,000,000 |
| 2020-12-16 | Invus Advisors, L.l.c. (Director) | Buy | 10,937,500 | 3.20 | 35,000,000 |
| 2020-04-26 | Swain Judith L (Director) | Option Ex | 3,466 | .00 | 0 |
| 2020-04-26 | Amouyal Philippe (Director) | Option Ex | 3,466 | .00 | 0 |
| 2020-04-26 | Palantoni Frank (Director) | Option Ex | 3,466 | .00 | 0 |
| 2020-04-26 | Nies Alan S (Director) | Option Ex | 3,466 | .00 | 0 |
| 2020-04-26 | Barker Sam L (Director) | Option Ex | 3,466 | .00 | 0 |
| 2020-04-26 | Lefkowitz Robert J Md (Director) | Option Ex | 3,466 | .00 | 0 |
| 2020-04-26 | Sobecki Christopher J (Director) | Option Ex | 3,466 | .00 | 0 |
| 2020-04-26 | Debbane Raymond (Director) | Option Ex | 3,466 | .00 | 0 |
| 2020-02-28 | Crum Brian T (VP, General Counsel & Secr.) | Option Ex | 20,252 | .00 | 0 |
| 2020-02-28 | Santini Alexander A (EVP and CCO) | Option Ex | 36,263 | .00 | 0 |
| 2020-02-28 | Coats Lonnel (President and CEO) | Option Ex | 116,647 | .00 | 0 |
| 2020-02-28 | Lapuerta Pablo (EVP and CMO) | Option Ex | 38,846 | .00 | 0 |
| 2020-02-28 | Tyle Praveen (EVP, R&D) | Option Ex | 39,316 | .00 | 0 |
| 2020-02-28 | Main Alan J (EVP, Commercial Supply Ops) | Option Ex | 37,252 | .00 | 0 |
| 2020-02-28 | Wade Jeffrey L (EVP, Corp Adm Affairs and CFO) | Option Ex | 42,138 | .00 | 0 |
| 2019-09-18 | Santini Alexander A (EVP and CCO) | Buy | 4,500 | 3.38 | 15,187 |
| 2019-09-18 | Coats Lonnel (President and CEO) | Buy | 50,000 | 3.10 | 155,000 |
| 2019-09-17 | Coats Lonnel (President and CEO) | Buy | 50,000 | 3.12 | 156,250 |
| 2019-09-16 | Sobecki Christopher J (Director) | Buy | 25,000 | 2.52 | 63,049 |
| 2019-09-16 | Debbane Raymond (Director) | Buy | 93,773 | 2.70 | 253,374 |
| 2019-09-13 | Sobecki Christopher J (Director) | Buy | 99,249 | 2.38 | 236,708 |
| 2019-09-13 | Debbane Raymond (Director) | Buy | 206,742 | 2.42 | 491,253 |
| 2019-08-19 | Coats Lonnel (President and CEO) | Buy | 3,000 | 1.40 | 4,194 |
| 2019-08-16 | Coats Lonnel (President and CEO) | Buy | 37,000 | 1.34 | 49,617 |
| 2019-08-02 | Tessmer James F (VP, Finance & Accounting) | Buy | 10,000 | 1.14 | 11,399 |
| 2019-08-02 | Barker Sam L (Director) | Buy | 24,000 | 1.18 | 28,200 |
| 2019-02-28 | Santini Alexander A (EVP and CCO) | Option Ex | 13,408 | .00 | 0 |
| 2019-02-28 | Coats Lonnel (President and CEO) | Option Ex | 48,101 | .00 | 0 |
| 2019-02-28 | Lapuerta Pablo (EVP and CMO) | Option Ex | 19,932 | .00 | 0 |
| 2019-02-28 | Tessmer James F (VP, Finance & Accounting) | Option Ex | 10,226 | .00 | 0 |
| 2019-02-28 | Tyle Praveen (EVP, R&D) | Option Ex | 12,717 | .00 | 0 |
| 2019-02-28 | Main Alan J (EVP, Commercial Supply Ops) | Option Ex | 20,151 | .00 | 0 |
| 2019-02-28 | Wade Jeffrey L (EVP, Corp Adm Affairs and CFO) | Option Ex | 22,655 | .00 | 0 |
| 2018-06-28 | Invus Public Equities Advisors, Llc (Director) | Buy | 57,724 | 12.46 | 718,952 |
| 2018-06-27 | Invus Public Equities Advisors, Llc (Director) | Buy | 125,114 | 12.54 | 1,568,429 |
| 2018-06-21 | Invus Public Equities Advisors, Llc (Director) | Buy | 51,600 | 13.27 | 684,628 |
| 2018-06-20 | Invus Public Equities Advisors, Llc (Director) | Buy | 12,391 | 13.29 | 164,614 |
| 2018-06-19 | Invus Public Equities Advisors, Llc (Director) | Buy | 8,982 | 13.45 | 120,816 |
| 2018-06-18 | Invus Public Equities Advisors, Llc (Director) | Buy | 36,584 | 13.06 | 477,933 |
| 2018-06-14 | Invus Public Equities Advisors, Llc (Director) | Buy | 9,200 | 12.66 | 116,462 |
| 2018-06-12 | Invus Public Equities Advisors, Llc (Director) | Buy | 107,023 | 12.83 | 1,373,212 |
| 2018-06-11 | Invus Public Equities Advisors, Llc (Director) | Buy | 98,626 | 12.75 | 1,257,481 |
| 2018-06-08 | Tessmer James F (VP, Finance & Accounting) | Sale | 10,000 | 12.91 | 129,080 |
| 2018-06-08 | Tessmer James F (VP, Finance & Accounting) | Option Ex | 10,000 | 10.15 | 101,500 |
| 2018-06-08 | Invus Public Equities Advisors, Llc (Director) | Buy | 29,747 | 12.89 | 383,438 |
| 2018-06-07 | Invus Public Equities Advisors, Llc (Director) | Buy | 57,439 | 12.93 | 742,513 |
| 2018-06-06 | Invus Public Equities Advisors, Llc (Director) | Buy | 95,079 | 12.58 | 1,196,379 |
| 2018-06-05 | Invus Public Equities Advisors, Llc (Director) | Buy | 173,121 | 12.46 | 2,156,222 |
| 2018-06-04 | Invus Public Equities Advisors, Llc (Director) | Buy | 121,803 | 12.24 | 1,490,625 |
| 2018-06-01 | Invus Public Equities Advisors, Llc (Director) | Buy | 147,339 | 12.22 | 1,800,040 |
| 2018-05-31 | Invus Public Equities Advisors, Llc (Director) | Buy | 147,339 | 11.62 | 1,712,079 |
| 2018-05-30 | Invus Public Equities Advisors, Llc (Director) | Buy | 147,339 | 10.32 | 1,520,980 |
| 2018-05-29 | Invus Public Equities Advisors, Llc (Director) | Buy | 147,339 | 9.84 | 1,450,405 |
| 2018-05-25 | Invus Public Equities Advisors, Llc (Director) | Buy | 138,700 | 9.62 | 1,334,987 |
| 2018-05-23 | Santini Alexander A (EVP and CCO) | Buy | 745 | 9.78 | 7,286 |
| 2018-02-28 | Santini Alexander A (EVP and CCO) | Option Ex | 4,945 | .00 | 0 |
| 2018-02-28 | Coats Lonnel (President and CEO) | Option Ex | 24,588 | .00 | 0 |
| 2018-02-28 | Lapuerta Pablo (EVP and CMO) | Option Ex | 14,184 | .00 | 0 |
| 2018-02-28 | Tessmer James F (VP, Finance & Accounting) | Option Ex | 7,353 | .00 | 0 |
| 2018-02-28 | Tyle Praveen (EVP, R&D) | Option Ex | 2,990 | .00 | 0 |
| 2018-02-28 | Main Alan J (EVP, Commercial Supply Ops) | Option Ex | 14,533 | .00 | 0 |
| 2018-02-28 | Wade Jeffrey L (EVP, Corp Adm Affairs and CFO) | Option Ex | 16,028 | .00 | 0 |
| 2017-11-17 | Invus Public Equities Advisors, Llc (Director) | Buy | 50,000 | 9.85 | 492,500 |
| 2017-11-15 | Coats Lonnel (President and CEO) | Buy | 10,000 | 9.91 | 99,100 |
| 2017-11-15 | Invus Public Equities Advisors, Llc (Director) | Buy | 130,727 | 10.21 | 1,334,461 |
| 2017-11-14 | Invus Public Equities Advisors, Llc (Director) | Buy | 215,133 | 9.47 | 2,037,954 |
| 2017-11-14 | Wade Jeffrey L (EVP, Corp Adm Affairs and CFO) | Buy | 2,000 | 9.48 | 18,962 |
| 2017-11-13 | Invus Public Equities Advisors, Llc (Director) | Buy | 215,133 | 9.75 | 2,097,977 |
| 2017-11-10 | Invus Public Equities Advisors, Llc (Director) | Buy | 145,680 | 9.74 | 1,418,340 |
| 2017-09-15 | Coats Lonnel (President and CEO) | Buy | 30,000 | 12.55 | 376,590 |
| 2017-09-15 | Barker Sam L (Director) | Buy | 1,000 | 12.50 | 12,500 |
| 2017-02-28 | Santini Alexander A (EVP and CCO) | Option Ex | 2,352 | .00 | 0 |
| 2017-02-28 | Coats Lonnel (President and CEO) | Option Ex | 19,226 | .00 | 0 |
| 2017-02-28 | Lapuerta Pablo (EVP and CMO) | Option Ex | 14,099 | .00 | 0 |
| 2017-02-28 | Tessmer James F (VP, Finance & Accounting) | Option Ex | 6,939 | .00 | 0 |
| 2017-02-28 | Main Alan J (EVP, CMC and Supply Operations) | Option Ex | 14,391 | .00 | 0 |
| 2017-02-28 | Wade Jeffrey L (EVP, Corp Adm Affairs and CFO) | Option Ex | 15,659 | .00 | 0 |
| 2016-06-06 | Tessmer James F (VP, Finance & Accounting) | Sale | 1,500 | 15.00 | 22,500 |
| 2016-06-06 | Tessmer James F (VP, Finance & Accounting) | Option Ex | 1,500 | 6.23 | 9,345 |
| 2016-05-23 | Tessmer James F (VP, Finance & Accounting) | Sale | 6,000 | 13.00 | 78,000 |
| 2016-05-23 | Tessmer James F (VP, Finance & Accounting) | Option Ex | 6,000 | 6.23 | 37,380 |
| 2016-02-29 | Coats Lonnel (President and CEO) | Option Ex | 10,835 | .00 | 0 |
| 2016-02-29 | Lapuerta Pablo (EVP and CMO) | Option Ex | 11,728 | .00 | 0 |
| 2016-02-29 | Tessmer James F (VP, Finance & Accounting) | Option Ex | 5,828 | .00 | 0 |
| 2016-02-29 | Main Alan J (EVP, CMC and Supply Operations) | Option Ex | 12,807 | .00 | 0 |
| 2016-02-29 | Wade Jeffrey L (EVP, Corp Adm Affairs and CFO) | Option Ex | 13,949 | .00 | 0 |
| 2015-03-02 | Northcott John (VP, Marketing, Comm Strategy) | Option Ex | 11,250 | .00 | 0 |
| 2015-03-02 | Lapuerta Pablo (EVP and CMO) | Option Ex | 50,250 | .00 | 0 |
| 2015-03-02 | Tessmer James F (VP, Finance & Accounting) | Option Ex | 29,625 | .00 | 0 |
| 2015-03-02 | Main Alan J (EVP, CMC and Supply Operations) | Option Ex | 69,000 | .00 | 0 |
| 2015-03-02 | Wade Jeffrey L (EVP, Corp Adm Affairs and CFO) | Option Ex | 75,750 | .00 | 0 |
| 2014-12-12 | Debbane Raymond (Director) | Buy | 150,000 | .88 | 132,000 |
| 2014-12-10 | Debbane Raymond (Director) | Buy | 315,896 | .90 | 285,254 |
| 2014-11-26 | Invus Public Equities Advisors, Llc (Director) | Buy | 149,253,731 | 1.00 | 149,999,999 |
| 2014-02-28 | Lapuerta Pablo (EVP, Clin Dev and CMO) | Option Ex | 30,500 | .00 | 0 |
| 2014-02-28 | Tessmer James F (VP, Finance & Accounting) | Option Ex | 20,250 | .00 | 0 |
| 2014-02-28 | Main Alan J (EVP, Pharmaceutical Research) | Option Ex | 50,250 | .00 | 0 |
| 2014-02-28 | Zambrowicz Brian P (EVP, Chief Scientific Officer) | Option Ex | 62,750 | .00 | 0 |
| 2014-02-28 | Wade Jeffrey L (EVP, Corp Dev and CFO) | Option Ex | 55,250 | .00 | 0 |
| 2014-02-28 | Sands Arthur T (President & CEO) | Option Ex | 108,250 | .00 | 0 |
| 2013-02-28 | Lapuerta Pablo (EVP, Clin Dev and CMO) | Option Ex | 13,000 | .00 | 0 |
| 2013-02-28 | Tessmer James F (VP, Finance & Accounting) | Option Ex | 14,250 | .00 | 0 |
| 2013-02-28 | Main Alan J (EVP, Pharmaceutical Research) | Option Ex | 33,750 | .00 | 0 |
| 2013-02-28 | Zambrowicz Brian P (EVP, Chief Scientific Officer) | Option Ex | 42,750 | .00 | 0 |
| 2013-02-28 | Wade Jeffrey L (EVP, Corp Dev and CFO) | Option Ex | 38,250 | .00 | 0 |
| 2013-02-28 | Sands Arthur T (President & CEO) | Option Ex | 73,250 | .00 | 0 |
| 2013-01-31 | Tessmer James F (VP, Finance & Accounting) | Option Ex | 13,200 | .00 | 0 |
| 2013-01-31 | Main Alan J (EVP, Pharmaceutical Research) | Option Ex | 31,600 | .00 | 0 |
| 2013-01-31 | Zambrowicz Brian P (EVP, Chief Scientific Officer) | Option Ex | 42,100 | .00 | 0 |
| 2013-01-31 | Wade Jeffrey L (EVP, Corp Dev and CFO) | Option Ex | 31,600 | .00 | 0 |
| 2013-01-31 | Sands Arthur T (President & CEO) | Option Ex | 73,700 | .00 | 0 |
| 2012-10-23 | Minne Pascal (Director) | Buy | 3,000,000 | 2.25 | 6,750,000 |
| 2012-10-23 | Debbane Raymond (Director) | Buy | 3,000,000 | 2.25 | 6,750,000 |
| 2012-02-28 | Tessmer James F (VP, Finance & Accounting) | Option Ex | 7,500 | .00 | 0 |
| 2012-02-28 | Main Alan J (EVP, Pharmaceutical Research) | Option Ex | 16,250 | .00 | 0 |
| 2012-02-28 | Zambrowicz Brian P (EVP, Chief Scientific Officer) | Option Ex | 21,250 | .00 | 0 |
| 2012-02-28 | Wade Jeffrey L (EVP, Corp Dev and CFO) | Option Ex | 18,750 | .00 | 0 |
| 2012-02-28 | Sands Arthur T (President & CEO) | Option Ex | 36,250 | .00 | 0 |
| 2011-12-22 | Main Alan J (EVP, Pharmaceutical Research) | Option Ex | 19,211 | 1.13 | 21,708 |
| 2011-12-22 | Barker Sam L (Director) | Option Ex | 34,000 | 1.13 | 38,420 |
| 2011-12-22 | Sands Arthur T (President & CEO) | Option Ex | 25,000 | 1.13 | 28,249 |
| 2010-03-19 | Debbane Raymond (10% Owner) | Buy | 94,270,206 | 1.15 | 108,410,736 |
| 2009-10-22 | Barker Sam L | Buy | 19,000 | 1.56 | 29,735 |
| 2009-10-15 | Debbane Raymond (10% Owner) | Buy | 2,015,888 | 1.50 | 3,023,832 |
| 2009-10-14 | Debbane Raymond (10% Owner) | Buy | 13,439,257 | 1.50 | 20,158,885 |
| 2008-08-23 | Debbane Raymond (10% Owner) | Buy | 50,824,986 | 3.79 | 192,880,821 |
| 2008-04-18 | Barker Sam L (Director) | Buy | 40,000 | 1.97 | 78,720 |
| 2007-12-19 | Nies Alan S (Director) | Buy | 5,000 | 2.98 | 14,900 |
| 2007-06-26 | Rose Clayton Stuart (Director) | Buy | 15,000 | 3.19 | 47,850 |
| 2007-06-19 | Ishimoto Lance K (SVP, Intellectual Property) | Option Ex | 4,000 | 2.50 | 10,000 |
| 2007-05-15 | Piggott James R Phd (SVP of Pharm Bio) | Sale | 1,000 | 3.40 | 3,400 |
| 2007-03-29 | Sands Arthur T (Pres & CEO) | Sale | 190,000 | 3.60 | 684,000 |
| 2007-03-29 | Sands Arthur T (Pres & CEO) | Option Ex | 300,000 | 1.67 | 501,000 |
| 2007-02-01 | Zambrowicz Brian P (EVP, Research) | Sale | 52,300 | 3.89 | 203,447 |
| 2007-02-01 | Zambrowicz Brian P (EVP, Research) | Option Ex | 90,000 | 1.67 | 150,300 |
| 2006-08-18 | Mills Barry (Director) | Buy | 25,000 | 3.93 | 98,175 |
| 2006-04-18 | Sands Arthur T (Pres & CEO) | Sale | 11,690 | 5.10 | 59,618 |
| 2006-04-17 | Sands Arthur T (Pres & CEO) | Sale | 3,310 | 5.14 | 17,029 |
| 2006-03-23 | Piggott James R Phd (SVP of Pharm Bio) | Sale | 30,000 | 5.50 | 165,060 |
| 2006-03-23 | Piggott James R Phd (SVP of Pharm Bio) | Option Ex | 30,000 | 2.50 | 75,000 |
| 2006-01-04 | Gregory Julia P (EVP, Corp Dev and CF) | Sale | 7,200 | 3.80 | 27,360 |
| 2005-12-30 | Gregory Julia P (EVP, Corp Dev and CF) | Sale | 3,800 | 3.70 | 14,060 |
| 2005-10-13 | Caskey C Thomas (Director) | Buy | 1,000 | 3.40 | 3,400 |
| 2005-09-02 | Caskey C Thomas (Director) | Buy | 1,000 | 4.61 | 4,610 |
Insider trading activities including stock purchases, stock sales, and option exercises of LXRX listed in the above tables cannot be completely guaranteed as to their accuracy. For more insider trading information of Lexicon Pharmaceuticals, Inc. (symbol LXRX, CIK number 1062822) see the Securities and Exchange Commission (SEC) website.