Insider Trading History of Chang Carmen

The following table details the insider trading activities (stock purchases, stock sales, and stock option exercises) of Chang Carmen since 2019. This trader's CIK number is 1746342. At the time of last reporting, Chang Carmen was the Officer of Spyglass Pharma, Inc.. (stock ticker symbol SGP). Also see all insider trading activities at Spyglass Pharma, Inc..

Note that in the past Chang Carmen also reported insider trading activities as an insider of the following companies:

Yearly summary of insider trading at Akouos, Inc. (AKUS) by Chang Carmen

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2020	AKUS	588,235	$9,999,995	0	$0	0	$0

Yearly summary of insider trading at Savara Inc (SVRA) by Chang Carmen

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2023	SVRA	333,333	$999,999	0	$0	0	$0

Yearly summary of insider trading at Mbx Biosciences, Inc. (MBX) by Chang Carmen

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2024	MBX	500,000	$8,000,000	0	$0	0	$0

Yearly summary of insider trading at Genocea Biosciences, Inc. (GNCA) by Chang Carmen

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2022	GNCA	0	$0	10,376,936	$750,066	0	$0
2020	GNCA	3,151,260	$7,090,335	0	$0	0	$0
2019	GNCA	12,805,411	$14,685,631	0	$0	0	$0

Yearly summary of insider trading at Neuehealth, Inc. (NEUE) by Chang Carmen

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2025	NEUE	0	$0	3,915	$26,426	682,468	$6,824
2021	NEUE	1,944,444	$34,999,992	0	$0	0	$0

Yearly summary of insider trading at Trevi Therapeutics, Inc. (TRVI) by Chang Carmen

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2022	TRVI	3,580,526	$6,802,999	0	$0	0	$0
2021	TRVI	1,851,852	$0	0	$0	0	$0
2020	TRVI	0	$0	564	$1,500	0	$0
2019	TRVI	2,500,000	$25,000,000	0	$0	0	$0

Yearly summary of insider trading at Korro Bio, Inc. (KRRO) by Chang Carmen

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2024	KRRO	17,857	$999,992	0	$0	0	$0

Yearly summary of insider trading at Regulus Therapeutics Inc. (RGLS) by Chang Carmen

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2020	RGLS	4,398,602	$2,735,930	0	$0	0	$0
2019	RGLS	1,136,704	$1,227,640	0	$0	0	$0

Yearly summary of insider trading at Marker Therapeutics, Inc. (MRKR) by Chang Carmen

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2021	MRKR	5,714,285	$9,999,998	0	$0	0	$0

Yearly summary of insider trading at Spyglass Pharma, Inc. (SGP) by Chang Carmen

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2026	SGP	937,500	$15,000,000	0	$0	0	$0

Yearly summary of insider trading at Mirum Pharmaceuticals, Inc. (MIRM) by Chang Carmen

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2019	MIRM	450,000	$6,750,000	0	$0	0	$0

Yearly summary of insider trading at Metacrine, Inc. (MTCR) by Chang Carmen

		Insider Buying		Insider Sales		Option Exercises
Year	Symbol	Shares	Value	Shares	Value	Shares	Value
2021	MTCR	0	$0	497,270	$489,102	0	$0
2020	MTCR	769,230	$9,999,990	0	$0	0	$0

Insider trading activities at 12 companies by Chang Carmen:

1. Akouos, Inc. (AKUS)

2. Savara Inc (SVRA)

3. Mbx Biosciences, Inc. (MBX)

4. Genocea Biosciences, Inc. (GNCA)

5. Neuehealth, Inc. (NEUE)

6. Trevi Therapeutics, Inc. (TRVI)

7. Korro Bio, Inc. (KRRO)

8. Regulus Therapeutics Inc. (RGLS)

9. Marker Therapeutics, Inc. (MRKR)

10. Spyglass Pharma, Inc. (SGP)

11. Mirum Pharmaceuticals, Inc. (MIRM)

12. Metacrine, Inc. (MTCR)

Table 1. Insider trading of Akouos, Inc. (AKUS) by Chang Carmen

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2020-06-30	AKUS	Buy	588,235	17.00	9,999,995

Table 2. Insider trading of Savara Inc (SVRA) by Chang Carmen

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2023-07-17	SVRA	Buy	333,333	3.00	999,999

Table 3. Insider trading of Mbx Biosciences, Inc. (MBX) by Chang Carmen

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2024-09-16	MBX	Buy	500,000	16.00	8,000,000

Table 4. Insider trading of Genocea Biosciences, Inc. (GNCA) by Chang Carmen

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2022-05-25	GNCA	Sale	4,445,093	.08	364,497
2022-05-24	GNCA	Sale	5,931,843	.07	385,569
2020-07-24	GNCA	Buy	3,151,260	2.25	7,090,335
2019-06-24	GNCA	Buy	2,857,142	3.50	9,999,997
2019-02-14	GNCA	Buy	9,948,269	.47	4,685,634

Table 5. Insider trading of Neuehealth, Inc. (NEUE) by Chang Carmen

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2025-10-02	NEUE	Option Ex	682,468	.01	6,824
2025-10-02	NEUE	Sale	3,915	6.75	26,426
2021-06-28	BHG	Buy	1,944,444	18.00	34,999,992

Table 6. Insider trading of Trevi Therapeutics, Inc. (TRVI) by Chang Carmen

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2022-04-11	TRVI	Buy	3,580,526	1.90	6,802,999
2021-10-18	TRVI	Buy	1,851,852	.00	0
2020-04-03	TRVI	Sale	564	2.66	1,500
2019-05-09	TRVI	Buy	2,500,000	10.00	25,000,000

Table 7. Insider trading of Korro Bio, Inc. (KRRO) by Chang Carmen

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2024-04-22	KRRO	Buy	17,857	56.00	999,992

Table 8. Insider trading of Regulus Therapeutics Inc. (RGLS) by Chang Carmen

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2020-12-04	RGLS	Buy	4,398,602	.62	2,735,930
2019-05-07	RGLS	Buy	1,136,704	1.08	1,227,640

Table 9. Insider trading of Marker Therapeutics, Inc. (MRKR) by Chang Carmen

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2021-03-16	MRKR	Buy	5,714,285	1.75	9,999,998

Table 10. Insider trading of Spyglass Pharma, Inc. (SGP) by Chang Carmen

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2026-02-09	SGP	Buy	937,500	16.00	15,000,000

Table 11. Insider trading of Mirum Pharmaceuticals, Inc. (MIRM) by Chang Carmen

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2019-07-22	MIRM	Buy	450,000	15.00	6,750,000

Table 12. Insider trading of Metacrine, Inc. (MTCR) by Chang Carmen

Trade Date	Symbol	Trade Type	Shares	Price ($)	Value ($)
2021-12-10	MTCR	Sale	37,570	1.32	49,629
2021-12-22	MTCR	Sale	459,700	.96	439,473
2020-09-18	MTCR	Buy	769,230	13.00	9,999,990

Insider trading activities including stock purchases, stock sales, and option exercises listed in the above table cannot be completely guaranteed as to their accuracy. For more information regarding the trades made by Chang Carmen (Officer of Spyglass Pharma, Inc. at the time of this reporting) see the Securities and Exchange Commission (SEC) website.

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